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Research Interest:
Genes underlying disorders in lipid and glucose metabolism
We are interested in identifying genes that underlie abnormalities in lipid and glucose metabolism using the mouse as a model. Much of our recent work has focused on the fatty liver dystrophy (fld) mutation, which results in lipodystrophy (lack of fat tissue), insulin resistance, and increased susceptibility to atherosclerosis. Using a positional cloning approach, we identified the fld mutation in a novel gene that we named Lipin. We are studying the role of lipin in fat tissue development and metabolic disorders in several models, including engineered mouse strains, cultured cells, human adipose tissue, and invertebrate organisms. A second positional cloning project that is underway is aimed at isolating a gene mutation that confers resistance to hypercholesterolemia and atherosclerosis. We are also pleased to be a member of the BayGenomics consortium that is performing analysis of gene function in the mouse on a large scale using gene-trap technology.
Genes underlying disorders in lipid and glucose metabolism
We are interested in identifying genes that underlie abnormalities in lipid and glucose metabolism using the mouse as a model. Much of our recent work has focused on the fatty liver dystrophy (fld) mutation, which results in lipodystrophy (lack of fat tissue), insulin resistance, and increased susceptibility to atherosclerosis. Using a positional cloning approach, we identified the fld mutation in a novel gene that we named Lipin. We are studying the role of lipin in fat tissue development and metabolic disorders in several models, including engineered mouse strains, cultured cells, human adipose tissue, and invertebrate organisms. A second positional cloning project that is underway is aimed at isolating a gene mutation that confers resistance to hypercholesterolemia and atherosclerosis. We are also pleased to be a member of the BayGenomics consortium that is performing analysis of gene function in the mouse on a large scale using gene-trap technology.
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论文共 237 篇作者统计合作学者相似作者
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JOURNAL OF THE ENDOCRINE SOCIETYno. 4 (2024): bvae029-bvae029
Aracely Acevedo,Anthony E. Jones, Bezawit T. Danna,Rory Turner, Katrina P. Montales,Cristiane Benincá,Karen Reue,Orian S. Shirihai,Linsey Stiles,Martina Wallace,Yibin Wang,Ambre M. Bertholet,
Journal of Biological Chemistryno. 3 (2024): 105702-105702
Kevin J. Williams,Joseph P. Argus,Yue Zhu,Moses Q. Wilks,Beth N. Marbois,Autumn G. York,Yoko Kidani, Alexandra L. Pourzia,David Akhavan,Dominique N. Lisiero,Evangelia Komisopoulou, Amy H. Henkin,
crossref(2023)
FRONTIERS IN ENDOCRINOLOGY (2023): 1304050-1304050
Kevin J. Williams,Joseph P. Argus,Yue Zhu,Moses Q. Wilks,Beth N. Marbois,Autumn G. York,Yoko Kidani, Alexandra L. Pourzia,David Akhavan,Dominique N. Lisiero,Evangelia Komisopoulou, Amy H. Henkin,
crossref(2023)
Kevin J. Williams,Joseph P. Argus,Yue Zhu,Moses Q. Wilks,Beth N. Marbois,Autumn G. York,Yoko Kidani, Alexandra L. Pourzia,David Akhavan,Dominique N. Lisiero,Evangelia Komisopoulou, Amy H. Henkin,
crossref(2023)
crossref(2023)
Kevin J. Williams,Joseph P. Argus,Yue Zhu,Moses Q. Wilks,Beth N. Marbois,Autumn G. York,Yoko Kidani, Alexandra L. Pourzia,David Akhavan,Dominique N. Lisiero,Evangelia Komisopoulou, Amy H. Henkin,
crossref(2023)
Kevin J. Williams,Joseph P. Argus,Yue Zhu,Moses Q. Wilks, Beth N. Marbois,Autumn G. York,Yoko Kidani, Alexandra L. Pourzia,David Akhavan,Dominique N. Lisiero,Evangelia Komisopoulou, Amy H. Henkin,
crossref(2023)
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