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Research Interests:
For over 20 years Dr. Karen H. Ashe has been engaged in the study of the molecular genetics, biochemistry and molecular biology of prion diseases and Alzheimer’s disease. Dr. Ashe's contributions are in three main areas: the genetics of human prion diseases; transgenic models of prion and Alzheimer’s diseases; and the molecular basis of memory loss in Alzheimer’s disease.
Dr. Ashe's lab created the Tg2576 transgenic mouse, which develops subtle memory problems and plaques composed of amyloid-beta protein. This mouse models the “pre-clinical” phase of Alzheimer’s disease. During this phase, the disease processes are underway in the brain, but people do not yet notice symptoms. This model of Alzheimer's disease is studied around the world today. The work continued with the creation of other mouse models of neurodegenerative disease, including developing the rTg4510 mouse that models another biological sign of Alzheimer's: neurofibrillary tangles made of tau protein.
Current research:
1.) Finding markers in blood and cerebral spinal fluid that will let us
detect Alzheimer’s disease at its earliest stages, before people notice symptoms -- and before there is irreplacable loss of large numbers of brain cells.
2.) Creation of an improved mouse model of Alzheimer’s disease that more
completely recapitulates the course of the human disease, exhibiting plaques, tangles, memory loss, and massive death of brain cells.
3.) Increasing the understanding of the basic mechanisms of Alzheimer’s
disease at the molecular level so that an intervention in the process might be found to halt the progress of the disease, specifically focusing on
Abeta*56 and Tau.
4.) Translation of safe and affordable compounds which have shown
results in mouse models of Alzheimer’s disease into a prevention strategy to reduce the incidence of the disease in humans through a collaboration of laboratory and clinical researchers.
Research Interests
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iScienceno. 3 (2024): 109239-109239
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