基本信息
views: 39
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
My research endeavors have defined optimal antithrombotic therapy for stroke prevention, clarified the role of high dose vitamins for treatment of hyperhomocysteinemia, and provided insight into the pathophysiology of ischemic stroke. I was the principal investigator of the NINDS P50 Partners Specialized Program of Translational Research in Acute Stroke (SPOTRIAS) and the American Heart Association supported Harvard Bugher Center for Stroke Prevention and Genetics Research, and am currently the Principal Neurologist on the Insulin Resistance Intervention after Stroke trial. I am committed to mentoring patient-oriented research of medical students, residents, and fellows.
My current research focus has been on the interaction between oxidative stress and matrix metalloproteinases to better define the mechanism of injury in acute stroke, and identify potential targets for intervention. We are examining dietary factors as they contribute to basal antioxidant capacity, and exploring in vivo effects of acute and chronic inflammation on oxidative stress. Furthermore, we have developed a unique semi-automated process for analyzing white matter disease, a silent and insidious manifestation of cerebrovascular disease, which will enable us to identify the contributions of genetic polymorphisms, oxidative stress, and cerebral blood flow on the pathophysiology of this process.
My current research focus has been on the interaction between oxidative stress and matrix metalloproteinases to better define the mechanism of injury in acute stroke, and identify potential targets for intervention. We are examining dietary factors as they contribute to basal antioxidant capacity, and exploring in vivo effects of acute and chronic inflammation on oxidative stress. Furthermore, we have developed a unique semi-automated process for analyzing white matter disease, a silent and insidious manifestation of cerebrovascular disease, which will enable us to identify the contributions of genetic polymorphisms, oxidative stress, and cerebral blood flow on the pathophysiology of this process.
Research Interests
Papers共 598 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
World Neurosurgery: X (2024): 100320-100320
Christoph Stretz, John E Paddock,Tina M Burton,Tatiana Bakaeva, Melissa Freeman, Aparna Choudhury, Shadi Yaghi,Karen L Furie,Matthew Schrag, Brian C MacGrory
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Associationno. 4 (2024): 107610-107610
Ariyaporn Haripottawekul,Elijah M Persad-Paisley, Saba Paracha, Deena Haque,Alizeh Shamshad,Karen L Furie,Michael E Reznik,Ali Mahta
World neurosurgery (2024): e582-e590
Liqi Shu, Naomi Jack,Adam de Havenon, Eric D Goldstein, Farhan Khan,Thanh N Nguyen,Nils Henninger,James E Siegler,Christoph Stretz, Elizabeth Perelstein, Narendra Kala, Maheen Rana,
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Associationpp.107839-107839, (2024)
Gustavo Saposnik,Cheryl Bushnell,Jonathan M. Coutinho,Thalia S. Field,Karen L. Furie,Najibah Galadanci,Wayneho Kam, Fenella C. Kirkham, Norma D. McNair,Aneesh B. Singhal, Vincent Thijs,Victor X. D. Yang
STROKEno. 3 (2024): E77-E90
Daniel Mandel,Liqi Shu, Kelly Pan,Karl V Baumgartner, Vishnu Dantu,Eric Goldstein,Tina Burton,Karen L Furie, Shadi Yaghi
Strokeno. Suppl_1 (2023)
Mu Ji Hwang, Crystal Sosa,Eric D Goldstein,Christoph Stretz,Gino Paolucci,Narendra Kala, Colleen R DeMoranville, Elizabeth Perelstein,Melissa Harmon,Tina M Burton,Daniel Mandel,Karen L Furie,
Strokeno. Suppl_1 (2023)
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn