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Bio
My laboratory explores fundamental mechanisms that govern vascular function in health and disease with a special emphasis on the molecular underpinnings of reduction-oxidation (redox) mechanisms
1. Post-translational regulation of the aging protein p66shc which promote oxidative stress in the setting of diabetes, hypercholesterolemia. 2. Post-translational redox modifications that regulate the SIRTIUN1 (SIRT1) deacetylase. 3. Role of p66shc in redox-regulated platelet function 4. Transcriptional and epigenetic regulation of p66shc and SIRT1. 5. Micro-RNA-mediated mechanisms which govern vascular function and cholesterol metabolism that are modulated by the gut microbiome. 6. Micro-RNA-dependent redox pathways that are governed by the oxidative stress protein p66shc 7. SIRT1-mediated post-translational regulation of the cardiac sodium channel.
Research Interests
Papers共 176 篇Author StatisticsCo-AuthorSimilar Experts
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Jin-Young Yoon,Alexander M. Greiner,Julia S. Jacobs,Young-Rae Kim, Tyler P. Rasmussen, William J. Kutschke, Daniel S. Matasic,Ajit Vikram, Ravinder R. Gaddam, Haider Mehdi,Kaikobad Irani,Barry London
Jun Sun,M. Nedim Ince,Clara Abraham,Terrence Barrett, Lisa A. Brenner,Yingzi Cong, Reza Dashti,Pradeep K. Dudeja,David Elliott,Thomas S. Griffith,Peter S. Heeger,Andrew Hoisington,
GUT MICROBESno. 2 (2023): 2267180-2267180
Zhiyong Zhu, Zhan Gao,Biyi Chen,Duane D Hall,Rachel Minerath,Olha Koval,Ana Sierra,Ekaterina Subbotina, Xiaoyi Zhu,Young Rae Kim, Jun Yang,Isabella Grumbach,
Ravinder R. Gaddam,Karishma Dhuri, Yung-Rae Kim,Julia S. Jacobs,Vikas Kumar,Qiuxia Li,Kaikobad Irani,Raman Bahal,Ajit Vikram
Circulation Researchno. Suppl_1 (2022)
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Author Statistics
#Papers: 176
#Citation: 17537
H-Index: 55
G-Index: 125
Sociability: 6
Diversity: 3
Activity: 29
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