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Our lab studies members of the nuclear receptor (NR) superfamily, an essential class of metazoan transcriptional regulatory factors. Upon binding cognate hormones, we showed that the glucocoticoid receptor (GR), the founding member of the superfamily, binds to specific genomic sites termed glucocorticoid response elements (GREs), and activates or represses transcription of nearby target genes; regulation, it appeared, would be elegant and simple. Since those discoveries in the early 1980’s, we and others have come to appreciate that metazoan transcriptional regulation is indeed elegant, but far from simple. We now know, for example, that GREs are composite elements, comprised of specific GR binding sequences linked to gene-specific arrays of sequence motifs recognized by non-GR regulatory factors, and that response elements are nucleation centers for the dynamic assembly and disassembly of multifactor regulatory complexes containing gene-, cell- and physiologic state-specific combinations of roughly 102 different genome binding regulatory factors and coregulatory factors associated through protein:protein interactions.
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Papers共 88 篇Author StatisticsCo-AuthorSimilar Experts
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SCIENCEno. 6683 (2024): 571-571
biorxiv(2020)
BESTpp.139-148, (2020)
GRADUATE STEM EDUCATION FOR THE 21ST CENTURY (2018)
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#Papers: 87
#Citation: 8803
H-Index: 38
G-Index: 67
Sociability: 6
Diversity: 3
Activity: 9
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