基本信息
views: 10
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
Bio
Research interest: Work in my laboratory is aimed toward the understanding of molecular pathways that govern chronic kidney disease development.
Research details
Work in my laboratory is aimed towards the understanding of molecular pathways that govern chronic kidney disease development. We have two general areas of interest: hypothesis generating (high trough-put, translational) and mechanistic studies. Over the past 10 years we banked and analyzed (combined genetic, epigenetic and genomic approaches) a large number of healthy and diseased human kidney tissue samples. We hypothesize that integrative analysis of epigenetic and genetic settings in diseased cells can provide a rational basis for more accurately modeling the critical biological pathways involved in mediating the progressive phenotype in individual patients. We also predict that epigenomic integrative analysis can be used to determine the identity of chromatin and transcription factors that contribute mechanistically to aberrant transcriptional programming in chronic kidney disease, and that this information can be used for designing therapeutic strategies. We are specifically interested in defining cis-regulatory modules (promoters, enhancers and repressors) that govern the normal and altered epithelial phenotype in diseased kidneys.
In addition, we use genetic approaches and mouse as a model organism to test the role of candidate signaling molecules and regulatory pathways directly in vivo. The Cre/loxP and tet inducible transgenic technologies allow us to analyze the function of particular factors by deleting or overexpressing genes that encode them in specific cell types in the kidney. Specifically, we are working on determining the role of the Notch and Wnt/beta-catenin pathway in chronic kidney disease development, renal epithelial cell homeostasis, renal stem or progenitor cell function and differentiation. Our recent results highlight the role of embryonic programs in adult disease development.
Rotation Projects
There are several; please speak with Dr. Susztak.
Research details
Work in my laboratory is aimed towards the understanding of molecular pathways that govern chronic kidney disease development. We have two general areas of interest: hypothesis generating (high trough-put, translational) and mechanistic studies. Over the past 10 years we banked and analyzed (combined genetic, epigenetic and genomic approaches) a large number of healthy and diseased human kidney tissue samples. We hypothesize that integrative analysis of epigenetic and genetic settings in diseased cells can provide a rational basis for more accurately modeling the critical biological pathways involved in mediating the progressive phenotype in individual patients. We also predict that epigenomic integrative analysis can be used to determine the identity of chromatin and transcription factors that contribute mechanistically to aberrant transcriptional programming in chronic kidney disease, and that this information can be used for designing therapeutic strategies. We are specifically interested in defining cis-regulatory modules (promoters, enhancers and repressors) that govern the normal and altered epithelial phenotype in diseased kidneys.
In addition, we use genetic approaches and mouse as a model organism to test the role of candidate signaling molecules and regulatory pathways directly in vivo. The Cre/loxP and tet inducible transgenic technologies allow us to analyze the function of particular factors by deleting or overexpressing genes that encode them in specific cell types in the kidney. Specifically, we are working on determining the role of the Notch and Wnt/beta-catenin pathway in chronic kidney disease development, renal epithelial cell homeostasis, renal stem or progenitor cell function and differentiation. Our recent results highlight the role of embryonic programs in adult disease development.
Rotation Projects
There are several; please speak with Dr. Susztak.
Research Interests
Papers共 340 篇Author StatisticsCo-AuthorSimilar Experts
By YearBy Citation主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Yu-Cheng Tsai,Tsung-Han Hsieh, Yuan-Ru Liao,Ming-Tsun Tsai,Tzu-Ping Lin,Der-Yen Lee,Jihwan Park, Donggun Kim,Katalin Susztak, Shang-Feng Yang, Chih-Ching Lin,Szu-Yuan Li
Journal of the American Society of Nephrology (2024)
Kaishu Mason,Anuja Sathe,Paul R. Hess,Jiazhen Rong,Chi-Yun Wu,Emma Furth,Katalin Susztak, Jonathan Levinsohn,Hanlee P. Ji,Nancy Zhang
Chenyu Li,Katalin Susztak
American Journal of Kidney Diseases (2024)
Xiujie Liang,Hongbo Liu,Hailong Hu,Jianfu Zhou,Amin Abedini, Andrea Sanchez Navarro,Konstantin A Klötzer,Katalin Susztak
bioRxiv : the preprint server for biology (2024)
biorxiv(2024)
Bioinformatics advancesno. 1 (2024): vbae076-vbae076
Robin L. Baudier, Paula F. Orlandi,Wei Yang,Hsiang-Yu Chen, Nisha Bansal, J. Walker Blackston, Jing Chen,Rajat Deo,Mirela Dobre, Hua He,Jiang He,Ana C. Ricardo,
Kidney Medicineno. 8 (2024): 100850
Cited0Views0Bibtex
0
0
JOURNAL OF CLINICAL INVESTIGATIONno. 4 (2024)
Lele Song, Qinglan Li, Lingbo Xia, Arushi Eesha Sahay,Qi Qiu, Yuanyuan Li,Haitao Li, Kotaro Sasaki,Katalin Susztak,Hao Wu,Liling Wan
Nature communicationsno. 1 (2024): 5937-5937
Kidney internationalno. 1 (2024): 24-34
Load More
Author Statistics
Co-Author
Co-Institution
D-Core
- 合作者
- 学生
- 导师
Data Disclaimer
The page data are from open Internet sources, cooperative publishers and automatic analysis results through AI technology. We do not make any commitments and guarantees for the validity, accuracy, correctness, reliability, completeness and timeliness of the page data. If you have any questions, please contact us by email: report@aminer.cn