基本信息
浏览量:298
职业迁徙
个人简介
Studying human B and T cell pathologies genetically, in preclinical mouse models and through gene repair in hematopoietic stem cells and mature lymphocytes
We combine Cre/loxP- and CRISPR/Cas-mediated targeted mutagenesis to study hematopoietic development with an emphasis on B cell physiology and antibody responses; and pathologies such as B cell malignancies, diseases caused or impacted by Epstein-Barr-Virus infection (including Multiple Sclerosis), and primary immunodeficiencies. In the latter contexts we develop preclinical genetic mouse models, and genetically modify human and mouse hematopoietic cells like T and B lymphocytes and hematopoietic stem cells. To this end we have established highly efficient methods of gene repair in such cells, suitable for application in somatic cell therapy.
We combine Cre/loxP- and CRISPR/Cas-mediated targeted mutagenesis to study hematopoietic development with an emphasis on B cell physiology and antibody responses; and pathologies such as B cell malignancies, diseases caused or impacted by Epstein-Barr-Virus infection (including Multiple Sclerosis), and primary immunodeficiencies. In the latter contexts we develop preclinical genetic mouse models, and genetically modify human and mouse hematopoietic cells like T and B lymphocytes and hematopoietic stem cells. To this end we have established highly efficient methods of gene repair in such cells, suitable for application in somatic cell therapy.
研究兴趣
论文共 577 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Xun Li,Tristan Wirtz,Timm Weber,Mikhail Lebedin, Elijah D. Lowenstein,Thomas Sommermann, Andreas Zach,Tomoharu Yasuda,Kathrin de la Rosa,Van Trung Chu, Johannes H. Schulte,Ingo Mueller,
SCIENCE IMMUNOLOGYno. 92 (2024)
biorxiv(2024)
Neal N. Iwakoshi,Ann-Hwee Lee, Prasanth Vallabhajosyula,Kevin L. Otipoby,Klaus Rajewsky,Laurie H. Glimcher
NATURE IMMUNOLOGY (2024)
Xun Li,Tristan Wirtz,Timm Weber,Mikhail Lebedin, Elijah D Lowenstein,Thomas Sommermann, Andreas Zach,Tomoharu Yasuda,Kathrin de la Rosa,Van Trung Chu, Johannes H Schulte,Ingo Müller,
Science immunologyno. 92 (2024): eadi0042-eadi0042
Nature communicationsno. 1 (2023): 6947-18
Ermeng Xiong,Oliver Popp, Claudia Salomon,Philipp Mertins,Christine Kocks,Klaus Rajewsky,Van Trung Chu
Frontiers in Immunology (2023)
FRONTIERS IN IMMUNOLOGY (2023): 1331730-1331730
Caroline Hojer, Samantha Frankenberger,Lothar J. Strobl, Samantha Feicht,Kristina Djermanovic, Franziska Jagdhuber, Cornelia Hömig-Hölzel,Uta Ferch,Jürgen Ruland,Klaus Rajewsky,Ursula Zimber-Strobl
crossref(2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn