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DRUG DELIVERY
During wound healing, localized and temporally controlled delivery of growth factors promotes coordinated tissue repair. In the case of chronic wounds, local inflammation and/or infection can hijack these normal repair processes, preventing repair and resulting in significantly increased morbidity rates. Our approach to addressing these challenges involves peptide-based delivery vehicles that harness ECM interactions to induce high-efficiency drug delivery and improved cellular uptake. To this end, we are producing a variety of collagen-modified nanoparticles and demonstrating their interactions with ECM components for delivery of macromolecular and small-molecule drugs. Preliminary data suggest that these interactions improve the duration of cargo delivery in a variety of in vivo models.
DRUG DELIVERY
During wound healing, localized and temporally controlled delivery of growth factors promotes coordinated tissue repair. In the case of chronic wounds, local inflammation and/or infection can hijack these normal repair processes, preventing repair and resulting in significantly increased morbidity rates. Our approach to addressing these challenges involves peptide-based delivery vehicles that harness ECM interactions to induce high-efficiency drug delivery and improved cellular uptake. To this end, we are producing a variety of collagen-modified nanoparticles and demonstrating their interactions with ECM components for delivery of macromolecular and small-molecule drugs. Preliminary data suggest that these interactions improve the duration of cargo delivery in a variety of in vivo models.
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NATURE CHEMISTRYpp.1-12, (2024)
Biomacromoleculesno. 4 (2024): 2408-2422
Biomacromoleculesno. 8 (2023): 3729-3741
BIOENGINEERING & TRANSLATIONAL MEDICINEno. 3 (2023): n/a-n/a
ACS applied materials & interfacesno. 13 (2023): 16434-16447
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