基本信息
浏览量:0
职业迁徙
个人简介
The broad theme of my laboratory is innate immune cell recognition of pathogen or "danger" molecules, the responses generated, and their role in pathology. In the past I have been particularly interested in responses of cells to foreign nucleic acids. This started with our early publication of macrophage activation by extracellular bacterial DNA, now known to be mediated by Toll-like receptor 9 (TLR9). On the other hand, DNA in the cytosol of cells is detected as abnormal, and we found this caused macrophage death. Subsequently, we were one of the groups describing the AIM2 inflammasome, a large protein complex that mediates DNA-dependent cell death and inflammation.
We currently focus on Toll-like receptor 4 (TLR4) which is the receptor for bacterial LPS, inflammasome responses, novel responses to cytosolic DNA, as well as inflammatory processes in dengue virus pathology. In-depth understanding of these processes will provide new directions for drug development.
We currently focus on Toll-like receptor 4 (TLR4) which is the receptor for bacterial LPS, inflammasome responses, novel responses to cytosolic DNA, as well as inflammatory processes in dengue virus pathology. In-depth understanding of these processes will provide new directions for drug development.
研究兴趣
论文共 105 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRYno. 1 (2024)
European journal of immunologyno. 5 (2024): e2350515-e2350515
J. D. Nanson, T. W. Muusse, Y. Li, M. Pan, M. J. Landsberg,P. R. Vajjhala,T. Ve,K. J. Stacey,B. Kobe
Acta Crystallographica Section A Foundations and Advancesno. a2 (2023)
European journal of immunologyno. 7 (2023): e2250056-e2250056
JOURNAL OF VIROLOGYno. 11 (2023)
Timothy W. Muusse, Morris Y.L. Lee, Hyoyoung Kim,Marie-Odile Parat,Jeffrey D. Nanson,Bostjan Kobe,Parimala R. Vajjhala,Katryn J. Stacey
Journal of Biological Chemistryno. 12 (2022): 102666-102666
Nature communicationsno. 1 (2021): 2578-2578
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn