基本信息
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个人简介
Kenner C. Rice received his B.S. from Virginia Military Institute and his Ph.D. in organic chemistry from Georgia Tech. After U.S. Army service, postdoctoral study at Georgia Tech and industrial experience at Ciba-Geigy (now Novartis), he began his drug abuse research at NIH with his mentor, Dr. Everette L. May in 1974. He presently serves as Chief of the Laboratory of Medicinal Chemistry, NIDDK, which is the contemporary successor of the original analgesic program begun at NIH by Drs. Nathan Eddy, Lyndon Small and their associates in 1939. Dr. Rice's research is medicinal-chemistry-based and is directed toward the elucidation of the structure and function of neurotransmitter systems in the central nervous system and the development of medications for the treatment and prevention of drug abuse. Dr. Rice has designed and directed synthesis of many drugs and affinity ligands as research tools which have substantially advanced understanding of the action of drugs of abuse. He also designed and developed the NIH Opiate Total Synthesis, the only practical methodology for production by chemical synthesis of all medical narcotics and narcotic antagonists now derived from opium and their enantiomers. This methodology offers independence from opium, and opium poppy eradication as a strategy to eliminate heroin abuse. Dr. Rice has mentored about 60 postdoctoral fellows from 16 countries and lectured widely in academia, government and industry.
Selected Publications:
Selfridge, B. R., Deschamps, J. R., Arthur E. Jacobson, A. E., Rice, K. C. (2014). Synthesis of enantiopure 10-nornaltrexones in the search for toll-like receptor 4 (TLR-4) antagonists and opioid ligands. Journal of Organic Chemistry, 2014, 79(11), 5007-5018.
Xiong, W., Chen, S-H., He, L., Cheng, K., Zhao, Y-L., Chen, H., Li, D-P., Homanics, G. E., Peever, J., Rice, K. C., Wu, L-G., Pan, H-L., Zhang, L. (2014). Presynaptic glycine receptors as a potential therapeutic target in hyperekplexia disease. Nature Neuroscience, 2014, 17, 232-239.
Schank, J. R., King, C. E., Hui Sun, H., Cheng, K., Rice, K. C., Heilig, M., Weinshenker, D., Schroeder, J. P. The role of the neurokinin-1 receptor in stress-induced reinstatement of alcohol and cocaine seeking. Neuropsychopharmacology, 2014, 39, 1093-1101.
Matyas, G. R., Rice, K. C., Arthur E. Jacobson, A. E., Cheng, K., Li, F., Iyer, M. R., Alexander V. Mayorov, A. V., Beck, Z., Alving, C. R. Facial Recognition of Opiates: Type 1 Cross-Reactivities of Antibodies Induced by Hydrolytically Stable Haptenic Surrogates of Heroin, 6-Acetyl Morphine, and Morphine. Vaccine, 2014, 32, 1473-1479.
Theberge, F. R., Li, A., Kambhampati, S., Bossert, J. M., Baumann, M. H., Hutchinson, M. R., Rice, K. C., Watkin, L. R., Shaham, Y. Effect of Chronic Delivery of the Toll-Like Receptor 4 Antagonist (+)-Naltrexone on the Development of Incubation of Heroin Craving. Biological Psychiatry, 2013, 73, 729-737.
研究兴趣
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Robert W. Seaman, Kariann Lamon, Nicholas Whitton,Brian Latimer, Agnieszka Sulima,Kenner C. Rice, Kevin S. Murnane,Gregory T. Collins
BRAIN SCIENCESno. 3 (2024)
Robert W Seaman, David G Galindo, Benjamin T Stinson,Agnieszka Sulima,Kenner C Rice,Martin A Javors,Brett C Ginsburg,Gregory T Collins
bioRxiv : the preprint server for biology (2024)
Brenda M. Gannon, Lauren R. Fitzgerald, Christopher O. Godwin, Heidi D. Hughes-Meredith,Kenner C. Rice,William E. Fantegrossi
DRUG AND ALCOHOL DEPENDENCE (2024)
Hudson G Roth, Madhurima Das, Agnieszka Sulima, Dan Luo,Sophia Kaska, Thomas E Prisinzano,Andrew T Kerr, Arthur E Jacobson,Kenner C Rice
Journal of Pharmacology and Experimental Therapeuticspp.JPET-AR, (2024)
Brenda M. Gannon, Lauren R. Fitzgerald, Christopher O. Godwin, Heidi D. Hughes-Meredith,Kenner C. Rice,William E. Fantegrossi
Drug and alcohol dependence (2024): 111129-111129
Michelle R Doyle,Nina M Beltran, Mark S A Bushnell, Maaz Syed, Valeria Acosta, Marisa Desai,Kenner C Rice, Katherine M Serafine,Georgianna G Gould,Lynette C Daws,Gregory T Collins
bioRxiv : the preprint server for biology (2024)
Carol Paronis, Kristen E. George,Eric W. Bow,Eugene S. Gutman,Agnieszka Sulima,Kenner Rice,Arthur Jacobson,Jack Bergman
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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