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PhD “Lung clearance index (LCI) as a definitive surrogate endpoint for therapeutic interventions in Cystic Fibrosis”.
Background: LCI is a measure of ventilation heterogeneity shown to be more superior in less severe lung disease than the current gold standard of lung function. It is increasingly being utilised in clinical trials for cystic fibrosis (CF) but there is considerable variability in multiple breath washout techniques used i.e. equipment, test gas and analysis software.
Aims: To understand why LCI is different between two separate test gases. To determine what is the minimal clinically important difference for LCI and finally to see if LCI is in fact inferior in more advanced disease.
Synopsis: I am currently writing my data. I am excited that some of my ideas have come to fruition and that the more I read and consider the field I have more thoughts on what is required to develop not only myself but the research field.
Imperial College London (Jul 2010 – present) - Research Physiologist and PhD student.
I perform an array of lung function tests within the Royal Brompton Hospital including spirometry, gas transfer and more advanced/specialist tests including multiple breath washout and cardio pulmonary exercise tests on patients with CF. This gives me hands on experience with chronic disease patients in a hospital environment as well as advancing innovative techniques.
I am the lead research physiologist for a number of pharmaceutical and academic lead clinical trials. I not only complete physiological testing but I help to coordinate research visits. I attend various investigator meetings and have knowledge of study coordination i.e. ethical review, protocol generation and study applications. I am also working closely with the LCI core facility that provide certification and over-reading analysis of test results for sites worldwide.
Research Interests
Papers共 26 篇Author StatisticsCo-AuthorSimilar Experts
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Katie J Bayfield, Oliver Weinheimer,Anna Middleton,Christie Boyton,Rachel Fitzpatrick, Brendan Kennedy,Anneliese Blaxland,Geshani Jayasuriya, Neil Caplain, Mark O Wielpütz,Lifeng Yu,Craig J Galban,
Journal of Cystic Fibrosis (2024)
Journal of Cystic Fibrosis (2024)
The European respiratory journalno. 1 (2023): 2300286-2300286
Sarah M. Muller,Sundaresh Ram,Katie J. Bayfield, Julia H. Reuter, Sonja Gestewitz,Lifeng Yu,Mark O. Wielputz,Hans-Ulrich Kauczor,Claus P. Heussel,Terry E. Robinson,Brian J. Bartholmai,Charles R. Hatt,
MICCAI (3) (2023): 432-441
Ediane De Queiroz Andrade,Katie J Bayfield,Anneliese Blaxland,Alexander Wong,Patricia de Gouveia Belinelo,Peter D. Sly, Adam Collison, Vanessa E. Murphy,Peter G. Gibson,Joërg Mattes, Paul D. Robinson
Pediatric pulmonologyno. 4 (2022): 1089-1091
THORAXno. 12 (2021): 1255-1265
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Author Statistics
#Papers: 23
#Citation: 160
H-Index: 8
G-Index: 12
Sociability: 5
Diversity: 2
Activity: 4
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