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个人简介
My research focuses on tauopathies, a large categorization of neurodegenerative diseases, with the dominant one being Alzheimer’s disease. Tau is a microtubule-associated protein (MAPT) that stabilizes and protects neurons from degeneration. When tau no longer binds to microtubules, it forms neurofibrillary tangles and paired helical filaments leading to the pathology. It is unknown what causes this mechanism to occur. We have recently discovered that the MAPT gene forms circular RNAs that are translated into proteins that can contribute to the pathology. My research focuses on better understanding the function of the tau circular RNAs and their relation to disease. I co-founded CircCure Corporation as a biotech company to develop new drug technology to target circular RNAs for drug therapy in combating tauopathies.
研究兴趣
论文共 12 篇作者统计合作学者相似作者
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Giorgi Margvelani,Justin R. Welden, Andrea Arizaca Maquera,Jennifer E. Van Eyk,Christopher Murray,Sandra C. Miranda Sardon,Stefan Stamm
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASEno. 4 (2024): 167036-167036
Frontiers in molecular neuroscience (2023): 1141079-1141079
Journal of Biological Chemistryno. 3 (2023): 104231-S667
Justin Ralph Welden,Giorgi Margvelani,Karol Andrea Arizaca Maquera, Bhavani Gudlavalleti,Sandra C Miranda Sardón,Alexandre Rosa Campos,Noémie Robil, Daniel C Lee,Alvaro G Hernandez,Wang-Xia Wang,Jing Di,Pierre de la Grange,
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2020)
Journal of Visualized Experiments (2020)
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作者统计
#Papers: 9
#Citation: 99
H-Index: 3
G-Index: 9
Sociability: 4
Diversity: 0
Activity: 0
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