基本信息
浏览量:71
![](https://originalfileserver.aminer.cn/sys/aminer/icon/show-trajectory.png)
个人简介
Research in my laboratory is focused upon the role of the microbiome in human dysbiotic diseases. We study the human oral microbiome as our model system to understand the connection between microbial ecology and symbiosis/dysbiosis at mucosal sites in the human body. The cariogenic species Streptococcus mutans is our primary organism of interest for genetic studies of microbiome pathobiology. However, our research also often includes a variety of other oral microbiome species, especially for studies of interspecies interactions among the oral microbiota. We are also interested in the mechanisms of synergistic pathogenesis that occur between different microbiome species during dysbiosis. Few efficacious treatment options are available for the many types of chronic dysbiotic diseases, such as oral diseases, irritable bowel disease, urinary tract infections, etc. The treatment of such diseases poses a unique challenge because the few species associated with pathology naturally live amongst potentially hundreds of other beneficial species in mixed communities. Thus, the typical antibiotic treatment approaches used for many other types of infections are either ineffective or can result in detrimental side effects. Ultimately, effective solutions will require new ecological treatment strategies to reestablish a symbiotic microbiome.
For our S. mutans studies, we are currently focusing on two main research projects. The first project is focused upon post-transcriptional gene regulation. An abundance of recent evidence in a variety of pathogens indicates that most of the critical regulation of virulence occurs post-transcriptionally, yet remarkably little is known about prokaryotic post-transcriptional control mechanisms, especially for organisms involved in dysbiotic diseases. Of central interest is to determine how a diverse array of environmental stress signals can activate these pathways to modulate downstream gene expression. The second project involves a new class of prokaryotic signal transduction system that we discovered in S. mutans and now refer to as LytTR Regulatory Systems (LRS). LRS appear to be widely conserved in prokaryotes, but nearly all are currently uncharacterized. In S. mutans, LRS activation can trigger lethality. Therefore, we are interested to determine how LRS transduce sensory information as well as the mechanisms responsible for lethality.
For our polymicrobial infection studies, we have developed a murine abscess model that is critically dependent upon polymicrobial synergism for virulence. Key oral microbiome species in our model include Streptococcus anginosus, Fusobacterium nucleatum, Prevotella nigrescens, and Parvimonas/Peptostreptococcus species. In addition to oral abscesses, these species are routinely isolated from numerous extraoral infections, such as severe liver, lung, and brain abscesses, yet it is entirely unclear how and why these infections occur. These species are also found intimately associated with various types of malignant tumors. Our major interest is to use the polymicrobial infection model to understand how a pathogenic community can dysregulate the immune response and trigger immunopathology, which is a hallmark of all chronic inflammatory dysbiotic diseases.
Memberships and associations
American Association of Dental Research Science Information Committee
International Association for Dental Research (IADR) & American Association for Dental Research (AADR)
American Society for Microbiology (ASM)
Standing member of the NIH Oral, Dental, and Craniofacial Sciences (ODCS) study section
Honors and awards
2019 OHSU Faculty Senate Award for Research
2018 recipient of the NIDCR SOAR Award R35
Areas of interest
Dentistry
Microbiome
Symbiosis and Dysbiosis
Biofilm
Bacterial Genetics
For our S. mutans studies, we are currently focusing on two main research projects. The first project is focused upon post-transcriptional gene regulation. An abundance of recent evidence in a variety of pathogens indicates that most of the critical regulation of virulence occurs post-transcriptionally, yet remarkably little is known about prokaryotic post-transcriptional control mechanisms, especially for organisms involved in dysbiotic diseases. Of central interest is to determine how a diverse array of environmental stress signals can activate these pathways to modulate downstream gene expression. The second project involves a new class of prokaryotic signal transduction system that we discovered in S. mutans and now refer to as LytTR Regulatory Systems (LRS). LRS appear to be widely conserved in prokaryotes, but nearly all are currently uncharacterized. In S. mutans, LRS activation can trigger lethality. Therefore, we are interested to determine how LRS transduce sensory information as well as the mechanisms responsible for lethality.
For our polymicrobial infection studies, we have developed a murine abscess model that is critically dependent upon polymicrobial synergism for virulence. Key oral microbiome species in our model include Streptococcus anginosus, Fusobacterium nucleatum, Prevotella nigrescens, and Parvimonas/Peptostreptococcus species. In addition to oral abscesses, these species are routinely isolated from numerous extraoral infections, such as severe liver, lung, and brain abscesses, yet it is entirely unclear how and why these infections occur. These species are also found intimately associated with various types of malignant tumors. Our major interest is to use the polymicrobial infection model to understand how a pathogenic community can dysregulate the immune response and trigger immunopathology, which is a hallmark of all chronic inflammatory dysbiotic diseases.
Memberships and associations
American Association of Dental Research Science Information Committee
International Association for Dental Research (IADR) & American Association for Dental Research (AADR)
American Society for Microbiology (ASM)
Standing member of the NIH Oral, Dental, and Craniofacial Sciences (ODCS) study section
Honors and awards
2019 OHSU Faculty Senate Award for Research
2018 recipient of the NIDCR SOAR Award R35
Areas of interest
Dentistry
Microbiome
Symbiosis and Dysbiosis
Biofilm
Bacterial Genetics
研究兴趣
论文共 123 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Frontiers in oral health (2024): 1413842-1413842
APPLIED AND ENVIRONMENTAL MICROBIOLOGYno. 4 (2024): e0150023-e0150023
Microbiology spectrumno. 6 (2024): e0051724-e0051724
MICROBIOLOGY SPECTRUMno. 2 (2024): e0369123-e0369123
Madeline Krieger,Yasser M. Abdelrahman,Dongseok Choi,Elizabeth A. Palmer, Anna Yoo,Sean Mcguire,Jens Kreth,Justin Merritt
CELL HOST & MICROBEno. 4 (2024): 479-488.e4
Dustin L. Higashi, Anh Nguyen,Hua Qin, Christina Borland,Elizabeth A. Palmer, Nicolas Biais,Jens Kreth,Justin Merritt
MICROBIOLOGY RESOURCE ANNOUNCEMENTSpp.e0031524-e0031524, (2024)
Frontiers in oral health (2024): 1410786-1410786
Madeline Krieger,Yasser M. AbdelRahman,Dongseok Choi,Elizabeth A. Palmer, Anna Yoo,Sean McGuire,Jens Kreth,Justin Merritt
bioRxiv : the preprint server for biology (2023)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn