基本信息
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Career Trajectory
Bio
The Hanes lab is focused on the development of advanced delivery systems to make drugs, vaccines, and nucleic acid based therapies more effective. A focus of our research is to develop the fundamental and applied knowledge needed to create biomaterial-based nanoparticles that overcome long-standing biological barriers and, thereby, enhance the efficiency of drug and nucleic acid delivery to specific sites in the body. To guide our development of improved drug carrier systems, we use state-of-the-art biophysical tools, including high-resolution particle tracking techniques, to quantify the nanoscopic movements of thousands of individual polymeric drug and gene nanocarriers in complex biological environments, especially in tissues such as the brain, extracellular barriers such as mucus gels, and inside live cells. Our lab has used new insights from our fundamental work to develop technologies that have led to the launch of companies that are developing products for humans. One example is the discovery of methods to make nanoparticles that rapidly penetrate human mucus barriers, which has led to new research into the development of nanoparticle-based drugs or nucleic acid therapies to prevent or treat diseases or conditions such as ocular inflammation, cystic fibrosis, asthma, chronic obstructive pulmonary disorder, inflammatory bowel disease, lung and cervical cancer, sexually transmitted infections, and more. Another example is the discovery of methods to produce biodegradable polymers that contain anti-angiogenic drugs built into the polymeric backbone; these systems are now being developed in industry to treat cancer and ocular diseases like age-related macular degeneration and diabetic retinopathy.
Research Interests
Papers共 332 篇Author StatisticsCo-AuthorSimilar Experts
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Karina Negron,Gijung Kwak, Heng Wang, Haolin Li, Yi‐Ting Huang,Shun‐Wen Chen,Betty Tyler,Charles G. Eberhart,Justin Hanes,Jung Soo Suk
ACS biomaterials science & engineeringno. 8 (2023): 4567-4572
Feihu Wang, Qian Huang,Hao Su,Mingjiao Sun,Zeyu Wang,Ziqi Chen, Mengzhen Zheng,Rami W. Chakroun,Maya K. Monroe, Daiqing Chen,Zongyuan Wang,Noah Gorelick,
Proceedings of the National Academy of Sciences of the United States of Americano. 18 (2023)
Nature Communicationsno. 1 (2023): 1-19
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCEno. 8 (2023)
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Journal of controlled release (2023): 371-380
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Author Statistics
#Papers: 334
#Citation: 31335
H-Index: 79
G-Index: 173
Sociability: 7
Diversity: 4
Activity: 66
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