基本信息
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Career Trajectory
Bio
Our mission is to develop novel mass spectrometry-based proteomics and metabolomics technologies, systems biology approaches, and to apply these tools to biomedical challenges (e.g. Alzheimer’s disease, cancer and immunity). We seek to obtain the full spectra of temporal and spatial omics data at bulk and single-cell-type levels from animal models and human clinical specimens. The multi-omics data include genome, transcriptome, proteome (the whole proteome and modified proteomes such as phosphoproteome and ubiquitinome), metabolome, and interactome. Network analysis and integration of such multi-omics data with phenotypic information offer a systems or holistic view, for unbiased identification of central disease gene/protein/metabolite networks, functional modules and master regulators. Beyond the big data analysis, we develop mouse models for functional and mechanistic studies to validate the derived hypotheses. These studies provide novel insights into the pathogenesis for therapeutic intervention, and may discover disease biomarkers for precision medicine.
Research Interests
Papers共 377 篇Author StatisticsCo-AuthorSimilar Experts
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Sabina Ranjit, Jingwen Zhu,Tomoka Gose,Amanda Nourse,Vishwajeeth Pagala,Yao Wang,Aaron Pitre, Rebecca Crawford,Junmin Peng,Juwina Wijaya,Anjaparavanda P. Naren,John Schuetz
ASPET 2024 Annual Meeting Abstract - Drug Metabolism and Disposition (DMD) (2024)
Natureno. 8012 (2024): E12-E12
NATURE (2024)
NATURE CELL BIOLOGYno. 4 (2024): 660-660
Natureno. 8007 (2024): 442-449
Minghong He,Xinying Zong,Beisi Xu, Wenjie Qi, Wenjun Huang,Mohamed Nadhir Djekidel,Yang Zhang,Vishwajeeth R Pagala,Jun Li,Xiaolei Hao,Clifford Guy, Lu Bai,
The Journal of experimental medicineno. 9 (2024)
Hao Chen, Yunlin Fu, Mei Han,Xianlin Han,Ling Hao,Tao Huan,Lan Huang,Ming Huang, Qin Ji, Tao Jiang,Yong Jiang,Liang Li,
Naturepp.1-8, (2024)
Nature Cell Biologyno. 4 (2024): 1-1
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