Semaphorin signaling
Semaphorins contribute to various physiological activities, including neural circuit formation, bone metabolism, angiogenesis, cancer progression, and immunity. Plexins and neuropilins are known as the major receptors for semaphorins, and each semaphorin specifically binds to a specific receptor to transmit signals. In this laboratory, we aim to elucidate how semaphorins activate their receptors and transmit their signals.