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个人简介
Dr. Wu’s laboratory studies secondary injury processes following traumatic spinal cord and brain injury (SCI/TBI) and pharmacological/gene therapeutic interventions for CNS trauma. My ultimate goal is to understand the cellular and molecular mechanism of functional recovery after CNS trauma and to develop potentially therapeutic strategies. Specifically, my research dedicates to: (1) Elucidating molecular mechanisms responsible for SCI/TBI-induced CNS neuroinflammation and neurological dysfunction. (2) Addressing the function and the mechanisms of autophagy-lysosomal pathway and specific microRNAs in neuronal injury after SCI which could open a potential novel treatment avenue against SCI as well as identify candidate molecular targets for these manipulations; (3) Identifying the genetic and genomic factors that impact SCI-PAIN as well as identifying new therapeutic targets to reduce or eliminate SCI-PAIN, including a truncated isoform of the BDNF receptor tropomyosin related kinase B (trkB), trkB.T1 and NOX2. This may lead to effective therapeutic interventions that limit post-SCI cognitive decline and depression.
研究兴趣
论文共 117 篇作者统计合作学者相似作者
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Rodney M. Ritzel,Yun Li,Yun Jiao,Sarah J. Doran,Niaz Khan,Rebecca J. Henry, Kavitha Brunner,David J. Loane,Alan I. Faden, Gregory L. Szeto,Junfang Wu
Journal of Neuroinflammationno. 1 (2024): 1-20
Gary Guzman, Kaiden Anderson,Romeesa Khan, Trang Do, Patrick Devlin, Janelle Korf, Zhoufan Lei,Junfang Wu,Rodney Ritzel
JOURNAL OF NEUROTRAUMAno. 15-16 (2023): A118-A118
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Rodney M. Ritzel,Yun Li,Yun Jiao,Sarah J. Doran,Niaz Khan,Rebecca J. Henry, Kavitha Brunner,David J. Loane,Alan I. Faden, Gregory L. Szeto,Junfang Wu
Research Square (Research Square) (2023)
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ANESTHESIA AND ANALGESIA (2023): 1035-1037
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Nivedita Hegdekar,Chinmoy Sarkar,Sabrina Bustos,Rodney M Ritzel,Marie Hanscom, Prarthana Ravishankar, Deepika Philkana,Junfang Wu,David J Loane,Marta M Lipinski
ANESTHESIA AND ANALGESIA (2023): 1038-1040
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