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个人简介
His research interest lies in discovering and understanding novel receptor-ligand pathways with immune-modulatory functions and how to best utilize them as potential targets for cancer immunotherapy. During these years, Dr. Wang developed several genome-scale proprietary screening platforms leading to valuable industrial partnerships, some of which formed the basis of NextCure, Inc. He has discovered several first-in-class targets, such as FGL1/LAG-3 and Siglec-15, which represent novel tumor immune evasion mechanisms and new approaches for cancer immunotherapy. The first-in-human cancer clinical trials targeting the Siglec-15 pathway are currently ongoing at Yale and NYU, in addition to other sites. Moreover, Dr. Wang also examined the mechanisms of anti-tumor efficacy versus liver toxicity of agonistic anti-CD137 (4-1BB) therapy and provided new insights for alleviating liver pathology without disruption of anti-tumor immunity.Moving forward, Dr. Wang is planning to use innovative technologies to identify key mechanisms within the tumor microenvironment in the control of anti-tumor immunity and to design useful next-generation cancer immunotherapies with rational biomarkers.
研究兴趣
论文共 148 篇作者统计合作学者相似作者
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JOURNAL OF CLINICAL INVESTIGATIONno. 3 (2024)
Nanoscaleno. 25 (2024): 11863-11878
Trends in immunologyno. 3 (2024): 177-187
Ziva Moravec, Yue Zhao,Rhianne Voogd,Danielle R. Cook,Seon Kinrot, Benjamin Capra, Haiyan Yang, Brenda Raud,Jiayu Ou,Jiekun Xuan,Teng Wei,Lili Ren,
John L Silberstein, Jasper Du,Kun-Wei Chan, Jessica A Frank,Irimpan I Mathews, Yong Bin Kim, Jia You,Qiao Lu,Jia Liu,Elliot A Philips,Phillip Liu, Eric Rao,
Proceedings of the National Academy of Sciences of the United States of Americano. 12 (2024): e2310866121-e2310866121
Journal of Clinical Investigationno. 3 (2024)
Elliot A Philips,Jia Liu,Audun Kvalvaag,Alexander M Mørch,Anna S Tocheva,Charles Ng, Hong Liang,Ian M Ahearn,Ruimin Pan,Christina C Luo,Alexander Leithner, Zhihua Qin,
Science immunologyno. 93 (2024): eade6256-eade6256
Bing Song, Kaiwen Wang, Saiyang Na, Jia Yao,Farjana J Fattah,Mitchell S von Itzstein,Donghan M Yang, Jialiang Liu, Yaming Xue, Chaoying Liang,Yuzhi Guo,Indu Raman,
bioRxiv : the preprint server for biology (2024)
The Journal of clinical investigationno. 3 (2024)
International journal of molecular sciencesno. 11 (2023): 9658-9658
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