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个人简介
The focus of research in my laboratory is to elucidate how neurons establish individual identity in the developing nervous system and why only specific neuron subtypes are vulnerable in neurodegenerative diseases. We tackle these questions via studying non-coding RNAs and their roles during motor neuron generation and degeneration. My lab employs motor neurons generated from mouse and human embryonic (ES) and induced pluripotent (iPS) stem cells, as well as mouse animal models to investigate motor neuron development and disease. We have developed and generated a series of stem cells and animal models to study functions of microRNA and lncRNA by “gain-of-function” and “loss-od-function” approach. Besides elucidating the basic molecular mechanisms underlying the specification of neuronal diversity during CNS development, I apply the stem cell system to study motor neuron diseases. In particular, I have engaged in the establishment and study of patient-specific iPS cell-based models of Spinal Muscular Atrophy (SMA), Amyotrophic Lateral Sclerosis (ALS). iPS cell-derived motor neurons are used in my lab to perform deep sequencing from healthy and ALS motor neurons and to functionally characterize non-coding RNA pathology in the motor neurons. I am also a core member of the Neuroscience Program and RNA program in Academia Sinica, which provides a strong and solid consortium to give advice and exchange ideas for our projects. In summary, I have multidisciplinary approaches, from in vitro stem cells to in vivo mouse models, to study motor neuron development and degeneration.
研究兴趣
论文共 29 篇作者统计合作学者相似作者
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ISCIENCEno. 3 (2024): 109207-109207
Tai-Heng Chen,Shih-Hsin Chang, Yu-Fu Wu,Ya-Ping Yen, Fang-Yu Hsu,Yen-Chung Chen,Yang Ming,Ho-Chiang Hsu,Yi-Ching Su,Sheng-Tang Wong,Jui-Hung Hung,Shih-Hwa Chiou,
Molecular Therapy: Nucleic Acids (2023): 144-160
biorxiv(2021)
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作者统计
#Papers: 29
#Citation: 529
H-Index: 13
G-Index: 22
Sociability: 5
Diversity: 2
Activity: 31
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