基本信息
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职业迁徙
个人简介
Research Focus
Molecular Studies
Studies in molecular recognition and catalysis
We have developed a series of synthetic receptors for small biorelevant molecular targets. These systems are container molecules, deep cavitands, that more-or-less surround the targets and present them with functional groups. This arrangement allows isolation and direct observation of reactive intermediates and catalysis of reactions with large rate enhancements.
Molecular self-assembly and encapsulation
We introduced a series of molecular capsules which self-assemble in the presence of appropriate guest species. These have been prepared in a variety of shapes and sizes, from those appropriate for encapsulation of methane to those capable of encapsulating transition states of cycloaddition reactions. The capsules reveal the behavior of molecules in very small spaces and channel their reactions along previously unknown pathways. The capsules and cavitands represent the leading edge of techniques in physical organic chemistry and provide new sequestering agents for actinide ions.
Sensors and antidotes for chemical warfare agents
We have devised a means by which a large number of nerve agents are rapidly detected and detoxified. The tactic involves combining a fluorescent dye with a reactive nucleophile such as an oxime. Reaction with a nerve agent is followed by a rapid intramolecular cyclization that creates a new fluorophore and destroys the agent. Current research revolves around the selective recognition of agents and their destruction in a catalytic manner.
Protein surface mimetics
We have synthesized small molecule scaffolds that present amino acid side chains that mimic arrangements found in protein alpha helices and beta strands. We have prepared some structures that act as agonists for neuropeptide receptors and others that target proteins involved in innate immunity. Current research involves the design of structures that will interfere with the inflammation cascade that leads to sepsis.
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CHEMISTRY-A EUROPEAN JOURNALno. 13 (2024): e202303911-e202303911
Chinese Chemical Letterspp.109228-109228, (2023)
GREEN SYNTHESIS AND CATALYSISno. 1 (2023): 7-9
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Chemical communications (Cambridge, England)no. 59 (2023): 9056-9065
Chinese Chemical Lettersno. 5 (2022): 107834-107834
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