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个人简介
For the past fifteen years I have been studying the role of calcium release mediated by the inositol 1,4,5-trisphosphate receptor (InsP3R) in different cellular processes that include transcription, proliferation, autophagy and more recently in bioenergetics and metabolism.
My seminal work revealed that in unstimulated conditions, small InsP3R-mediated calcium release taken up by the mitochondria was essential to maintain cellular bioenergetics in all cell types. Inhibition of this signal causes an energetic stress that activates autophagy as a pro-survival mechanism. This ER-mitochondrial calcium communication has proven to be essential for the homeostasis of cancer and senescence cells which selectively die when it is inhibited. Given the negative impact that the accumulation of senescence cells have in healthspan and the role they play in cancer spread and relapse, we are focusing in understand the role of ER-mitochondrial communication in chemo-induce cellular senescence, the principal players involved and the signal transduction pathways underlying this communication with the final aim to developing pharmacological and molecular tools to modulate this inter-organelle relation and selectively target cancer and chemo-induce senescence cells.
研究兴趣
论文共 202 篇作者统计合作学者相似作者
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DIVERSITY-BASELno. 3 (2024)
Marcelo González-Aravena, Carmen Rotunno,César A. Cárdenas,Mariett Torres,Simon A. Morley, Jessica Hurley, Luis Caro-Lara,Karla Pozo, Cristóbal Galban,Rodolfo Rondon
Marine Pollution Bulletin (2024): 116257-116257
Biodiversity and Conservationno. 3 (2024): 929-948
Cell reports. Medicinepp.101593-101593, (2024)
Frontiers in Cell and Developmental Biology (2024): 1324158-1324158
Vicente Catalán-Salas,Pablo Sagredo, Williams Melgarejo,M.Verónica Donoso,J.Cesar Cárdenas,Armen Zakarian, Daniel Valdés,Claudio Acuña-Castillo,J. Pablo Huidobro-Toro
European Journal of Pharmacology (2024): 176636-176636
Brazilian Journal of Microbiologyno. 1 (2024): 487-497
Eduardo Silva-Pavez, Elizabeth Mendoza, Pablo Morgado-Cáceres, Ulises Ahumada-Castro, Galdo Bustos, Matías Kangme-Encalada, Amaia Lopez de Arbina, Andrea Puebla-Huerta, Felipe Muñoz, Lucas Cereceda, Manuel Varas-Godoy, Yessia Hidalgo,
Scientific reportsno. 1 (2024): 14178-14178
Andrea Puebla-Huerta,Hernán Huerta, Camila Quezada-Gutierez, Pablo Morgado-Cáceres, César Casanova-Canelo, Sergio Linsambarth, Osman Díaz-Rivera,José Alberto López-Domínguez,Sandra Rodríguez-López,Galdo Bustos,Eduardo Silva-Pavez,Alenka Lovy,
biorxiv(2024)
Rodolfo Rondon,Céline Cosseau,Elisa Bergami,César A. Cárdenas, Carolina Pérez-Toledo, Diego Alvarez, Jacqueline Aldridge,Alejandro Font, Ignacio Garrido,Francisco Santa Cruz, Garance Perrois,Teresa Balbi,
Marine Environmental Research (2024): 106539-106539
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