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个人简介
Clinical Specialties: Veterinary anatomic pathology, Veterinary orthopedic pathology, Equine laminitis, Equine gastrointestinal pathology, Equine microbiome Experimental Animal Models
Research Areas: Gastrointestinal pathology, Orthopedic pathology, Laminitis
My clinical, diagnostic and research expertise is veterinary anatomic pathology with special focus on orthopedic and gastrointestinal pathology. Current and past research projects have included clinical research, translational animal models of human and animal disease, and exploratory investigations including academic and industrial collaborations.
One focus of my orthopedic research includes translational animal models evaluating bone, joint and tendonous tissues. Current and past projects include analyses of orthopedic surgical procedures, biomaterials, and devices utilizing large animal models of human orthopedic disease including swine, sheep, goats, horses and dogs. Internal collaborations include Penn Vet's Comparative Orthopedic Research Laboratory (CORL: Drs. Dean Richardson, Tom Schaer, and Kyla Ortved) and the Penn Center for Musculoskeletal Disorders (PCMD). A collaboration with Dr. Nicky Mason (Department of Clinical Studies- Philadelphia) investigated a canine model of osteosarcoma investigating T-cell mediated immunotherapy targeting tumor osteoblasts expressing Her2/neu antigen. External collaborations include academic institutions and industry investigating murine fracture healing and gene-therapy for large animal models of naturally occurring osteoarthritis.
Another focus of orthopedic research is equine laminitis, including internal collaborations (Drs. van Eps and Galantino-Homer) and external collaborations (University of Queensland, Ohio State University, Oklahoma State University). Through correlation of clinical and pathological data with transcriptomic and proteomic data, the goals of the research are 1) to better understand the pathogenesis of laminitis and 2) to identify potential early biomarkers and molecular targets of laminitis for disease prevention and early therapeutic intervention. One unique aspect of the research involves the interaction among different tissue interfaces including epidermal and dermal lamellae, neurovascular structurs, and the distal phalanx.
My secondary research focus involves equine gastrointestinal pathology and the equine intestinal microbiome. Collaborators include Dr. Southwood (Large Animal Emergency and Critical Care service), and Dr. Pitta (Agricultural Systems and Microbial Genomics laboratory) from the Department of Clinical Studies-New Bolton Center. Current and past investigations include establishment of normal parameters for gastrointestinal architecture and resident inflammatory cell populations, evaluation of the effect of peri-operative antimicrobials on the equine fecal microbiome for elective surgical procedures, and the differences in fecal microbiome and intestinal micro-architecture in horses presenting for acute and recurrent colic.
Research Areas: Gastrointestinal pathology, Orthopedic pathology, Laminitis
My clinical, diagnostic and research expertise is veterinary anatomic pathology with special focus on orthopedic and gastrointestinal pathology. Current and past research projects have included clinical research, translational animal models of human and animal disease, and exploratory investigations including academic and industrial collaborations.
One focus of my orthopedic research includes translational animal models evaluating bone, joint and tendonous tissues. Current and past projects include analyses of orthopedic surgical procedures, biomaterials, and devices utilizing large animal models of human orthopedic disease including swine, sheep, goats, horses and dogs. Internal collaborations include Penn Vet's Comparative Orthopedic Research Laboratory (CORL: Drs. Dean Richardson, Tom Schaer, and Kyla Ortved) and the Penn Center for Musculoskeletal Disorders (PCMD). A collaboration with Dr. Nicky Mason (Department of Clinical Studies- Philadelphia) investigated a canine model of osteosarcoma investigating T-cell mediated immunotherapy targeting tumor osteoblasts expressing Her2/neu antigen. External collaborations include academic institutions and industry investigating murine fracture healing and gene-therapy for large animal models of naturally occurring osteoarthritis.
Another focus of orthopedic research is equine laminitis, including internal collaborations (Drs. van Eps and Galantino-Homer) and external collaborations (University of Queensland, Ohio State University, Oklahoma State University). Through correlation of clinical and pathological data with transcriptomic and proteomic data, the goals of the research are 1) to better understand the pathogenesis of laminitis and 2) to identify potential early biomarkers and molecular targets of laminitis for disease prevention and early therapeutic intervention. One unique aspect of the research involves the interaction among different tissue interfaces including epidermal and dermal lamellae, neurovascular structurs, and the distal phalanx.
My secondary research focus involves equine gastrointestinal pathology and the equine intestinal microbiome. Collaborators include Dr. Southwood (Large Animal Emergency and Critical Care service), and Dr. Pitta (Agricultural Systems and Microbial Genomics laboratory) from the Department of Clinical Studies-New Bolton Center. Current and past investigations include establishment of normal parameters for gastrointestinal architecture and resident inflammatory cell populations, evaluation of the effect of peri-operative antimicrobials on the equine fecal microbiome for elective surgical procedures, and the differences in fecal microbiome and intestinal micro-architecture in horses presenting for acute and recurrent colic.
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Lynn M Pezzanite,Lyndah Chow,Julie B Engiles, Jade Kurihara, Cody Plaisance,Laurie R Goodrich,Steven Dow
Journal of the American Veterinary Medical Associationpp.1-10, (2024)
Katrijn D Whisenant, Mathieu Foucaud,Tom Mariën,David Levine,Dean W Richardson,Darko Stefanovski,Nicole M Scherrer,Julie B Engiles,Kyla Ortved
Veterinary surgery : VS (2024)
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY (2023)
Virusesno. 5 (2023): 1103-1103
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Jessica M Gilbertie,Thomas P Schaer,Julie B Engiles,Gabriela S Seiler, Bennett L Deddens,Alicia G Schubert,Megan E Jacob,Darko Stefanovski,Gordon Ruthel,Noreen J Hickok,Devorah M Stowe, Alexa Frink,
SSRN Electronic Journal (2022)
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