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Dr. Feigon pioneered the use of NMR to determine structures and dynamics of DNA and RNA. As a graduate student (1976-1982) she used correlation NMR spectroscopy to investigate the interactions of >90 different drugs with DNA and also published the first two dimensional FT NMR spectra of DNA duplexes, demonstrating that NOESY and COSY data could be used reveal structural details. During her postdoctoral work (1982-1985) she used NMR to study the conversion of B-DNA to Z-DNA, correlating B-DNA resonances with Z-DNA resonances in one of the first examples of exchange spectroscopy applied to macromolecules. Dr. Feigon’s early work as a faculty member at UCLA (1985 on) was seminal in defining the conformational variability of DNA. She published the first structures of DNA triplexes, quadruplexes, and aptamers, and her work has provided fundamental insights into DNA A-tract and protein induced bending, cation interactions with DNA, Hoogsteen base pairs, and drug binding to DNA. Her landmark 1992 structural studies of DNA quadruplexes formed by Oxytricha telomere repeats was seminal to the now burgeoning fields of G-quadruplex targeted anticancer and telomerase inhibiting drugs and DNA nanostructures. In the mid-1990s she began to turn her attention to understanding RNA folding and function, including studies of RNA aptamers, ribozymes, and riboswitches, and recognition of RNA by proteins. She solved the first solution structure of a riboswitch (preQ1) (2009) and set the standard for high resolution RNA structures determined by NMR. For all of this work, she has developed new NMR methods and applications for studying nucleic acids structure and dynamics, including assignments and detecting cation interactions. She has combined structural and functional studies of RNA-protein complexes to reveal essential determinants of protein recognition of single stranded and of double stranded RNA by RRMs and dsRBDs, respectively. She has made major contributions to understanding the structure, function, processing, and assembly of H/ACA RNPs, RNase III, and telomerase. Work on these projects as well as other non-coding and riboswitch RNAs is ongoing.
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Ke Hou,Peng Ge,Michael R Sawaya, Joshua L Dolinsky,Yuan Yang,Yi Xiao Jiang,Liisa Lutter,David R Boyer,Xinyi Cheng, Justin Pi, Jeffrey Zhang,Jiahui Lu,
bioRxiv : the preprint server for biology (2024)
Ke Hou,Peng Ge,Michael R. Sawaya, Joshua L. Dolinsky,Yuan Yang,Yi Xiao Jiang,Liisa Lutter,David R. Boyer,Xinyi Cheng, Justin Pi, Jeffrey Zhang,Jiahui Lu,
biorxiv(2024)
bioRxiv : the preprint server for biologyno. 1 (2023)
Yao He,Yaqiang Wang,Baocheng Liu, Christina Helmling,Lukas Sušac, Ryan Cheng,Z. Hong Zhou,Juli Feigon
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