基本信息
浏览量:0
职业迁徙
个人简介
Inflammasomes are multi-protein complexes that are responsible for the induction of proinflammatory cytokines and inflammatory cell death. They are unique in innate immune signaling because they can be triggered by a plethora of diverse signals from both pathogens and environmental danger. The research in our lab focuses on dissecting the molecular mechanisms of inflammasome pathways and studying how their dysfunction leads to defective host defense against various pathogenic microorganisms, as well as the impact on autoimmune diseases, neurodegeneration and metabolic syndromes. Our lab utilizes diverse and complementary approaches, including biochemical assays, confocal fluorescence imaging, CRISPR knockout/rescue and animal models. Our recent study has uncovered the unexpected role of trans-Golgi network dispersion in inflammasome activation, and we are currently interested in studying how pathogens are able to evade or hijack these cellular signals to counter the host defense. We believe that these studies will unveil potential therapeutic targets for infectious diseases and many other human health problems.
研究兴趣
论文共 6 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
crossref(2024)
Annual review of microbiology (2018): 447-478
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn