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My research vision for the Phillip tiME lab, at the interface of engineering and medicine, focuses on applying fundamental engineering principles to answer key questions in aging and cancer biology. To this end, our long term goal is to develop and translate discoveries and technologies from the laboratory into the medical arena to improve human health and longevity. Our initial approach is built on two overarching concepts/needs, which are to develop robust cell-based biomarkers of aging in health and disease (with the ability to stratify vulnerable individuals), and to establish research pipelines that explain the mechanistic relationships among age-related dysfunctions, disease progression and treatment responses.
To address these anticipated challenges, my approach is to leverage emerging technologies in longitudinal cell-based profiling (including single cell biophysical properties and ‘omics’), combined with modern data science approaches and clinical measures to comprehensively assess health, identify deviations from healthy aging-trajectories and elucidate the scale-dependence of aging. We anticipate that these approaches will lead to effective strategies to reduce age-associated disease burdens, control healthcare costs by delaying onset and disease progression, and extend the amount of time spent free of diseases, dysfunctions and disabilities (due to improved risk prediction and early detection). Alongside these core questions, we are keen on identifying how gender, demographics, social determinants of health and health disparities contribute to the overall aging outlook of individuals, and the propensities for interventions and course correction.
My research vision for the Phillip tiME lab, at the interface of engineering and medicine, focuses on applying fundamental engineering principles to answer key questions in aging and cancer biology. To this end, our long term goal is to develop and translate discoveries and technologies from the laboratory into the medical arena to improve human health and longevity. Our initial approach is built on two overarching concepts/needs, which are to develop robust cell-based biomarkers of aging in health and disease (with the ability to stratify vulnerable individuals), and to establish research pipelines that explain the mechanistic relationships among age-related dysfunctions, disease progression and treatment responses.
To address these anticipated challenges, my approach is to leverage emerging technologies in longitudinal cell-based profiling (including single cell biophysical properties and ‘omics’), combined with modern data science approaches and clinical measures to comprehensively assess health, identify deviations from healthy aging-trajectories and elucidate the scale-dependence of aging. We anticipate that these approaches will lead to effective strategies to reduce age-associated disease burdens, control healthcare costs by delaying onset and disease progression, and extend the amount of time spent free of diseases, dysfunctions and disabilities (due to improved risk prediction and early detection). Alongside these core questions, we are keen on identifying how gender, demographics, social determinants of health and health disparities contribute to the overall aging outlook of individuals, and the propensities for interventions and course correction.
研究兴趣
论文共 59 篇作者统计合作学者相似作者
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Sean M. Engels,Pratik Kamat, G. Stavros Pafilis,Yukang Li, Anshika Agrawal,Daniel J. Haller,Jude M. Phillip,Lydia M. Contreras
PNAS NEXUSno. 1 (2023): pgad415-pgad415
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Xiaomu Wei, M. Nieves Calvo-Vidal,Siwei Chen,Gang Wu,Maria V. Revuelta,Jian Sun,Jinghui Zhang,Michael F. Walsh,Kim E. Nichols,Vijai Joseph,Carrie Snyder,Celine M. Vachon,
crossref(2023)
Danilo Fiore, Luca Vincenzo Cappelli,Zhaoqi Liu,Nikita Kotlov, Maria Sorokina,Jude M. Phillip,Paul Zumbo,Liron Yoffe, Han Xueshuai, Claudia Pignataro,Paola Ghione,Valentina Fragliasso,
HemaSphereno. S3 (2023): e8686389-e8686389
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