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I run a multidisciplinary research group with expertise in X-ray crystallography, Biophysics, Protein Engineering and Bioinformatics tools aiming to provide knowledge of the three-dimensional structure of proteins and analysis of their various interactions and ligand complexes as a prerequisite for an in-depth understanding of any biological process. The research interests in my group encompass studies in the mechanisms of bacterial virulence and pathogenesis and the means of circumvent them. We focus on the structural biology of the bacterial surface proteins involved in key functions, such as binding of the pathogen to host cellular receptors, antibiotics resistance, cell division, pathogenesis mechanisms or the remodeling of the peptidoglycan framework, which represent important mechanisms in the process of disease.
With more than 200 structures deposited in Protein Data Bank, our group has a unique expertise in the field of structural and functional characterization of bacterial surface proteins involved in virulence. This expertise has been recognised with several reviews, book chapters, by participation in different European and North American consortia and by organization of important meetings in the field. As our projects involve profound characterization of each system in a multidimensional approach (biochemical, molecular, biomedical…) a large network of collaborations with many groups worldwide has been established.
Research Interests
Papers共 356 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Communicationsno. 1 (2024): 1-17
NUCLEIC ACIDS RESEARCHno. 4 (2024): 2045-2065
Jianwei Li, Yutong He, Xin Xu,Martin Alcorlo,Jian Shi,David I. Roper,Juan A. Hermoso,Lok-To Sham,Min Luo
biorxiv(2024)
FEBS letters (2024)
BOLETIN GEOLOGICO Y MINEROno. 1 (2024): 59-78
Nucleic acids researchno. 4 (2024): 2045-2065
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULESno. Pt 3 (2024): 127935-127935
Martín Alcorlo,Mohammed R Abdullah,Leif Steil, Francisco Sotomayor, Laura López-de Oro,Sonia de Castro,Sonsoles Velázquez,Thomas P Kohler,Elisabet Jiménez,Ana Medina,Isabel Usón,Lance E Keller,
PLoS pathogensno. 6 (2024): e1011883-e1011883
Akbar Espaillat,Laura Alvarez,Gabriel Torrens,Josy ter Beek,Vega Miguel-Ruano,Oihane Irazoki,Federico Gago,Juan A. Hermoso, Ronnie Per-Arne Berntsson,Felipe Cava
biorxiv(2023)
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