基本信息
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Bio
Juan C. Sáez studies the regulation and function of membrane channels (gap junction channels and hemichannels) composed of proteins called connexins or pannexins. The studies are conducted under physiological and pathophysiological conditions using exogenous expression systems or in primary cells of the nervous or immune system.
During the last decade, he has contributed to understand the involvement of these in the inflammatory response. Since opening of hemichannels is directly involved in the development of inflammatory responses that underlie tissue dysfunction he is searching for potent and selective blockers that could be used as therapeutic agents in diverse chronic diseases with an important inflammatory component.
During the last decade, he has contributed to understand the involvement of these in the inflammatory response. Since opening of hemichannels is directly involved in the development of inflammatory responses that underlie tissue dysfunction he is searching for potent and selective blockers that could be used as therapeutic agents in diverse chronic diseases with an important inflammatory component.
Research Interests
Papers共 351 篇Author StatisticsCo-AuthorSimilar Experts
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Methods in molecular biology (Clifton, N.J.) (2024): 87-95
Gonzalo I. Gómez,Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara,Luis A. Mellado, Claudio J. Martinez-Araya,Juan Prieto-Villalobos,Claudia García-Rodríguez, Natalia Sánchez,Juan C. Sáez,Fernando C. Ortíz,
Biological Researchno. 1 (2024): 1-19
Biological Researchno. 1 (2024): 1-19
NEUROSCIENCE (2024): 81-84
Neuroscience (2024)
Magdiel Salgado,Valeria Márquez-Miranda, Luciano Ferrada,Maximiliano Rojas, Gonzalo Poblete-Flores,Fernando D González-Nilo,Álvaro O Ardiles,Juan C Sáez
Proceedings of the National Academy of Sciences of the United States of Americano. 25 (2024): e2405468121-e2405468121
Gonzalo I Gómez,Claudia García-Rodríguez, Jesús E Marillán, Sergio A Vergara,Tanhia F Alvear, Arantza Farias-Pasten,Juan C Sáez,Mauricio A Retamal,Maximiliano Rovegno,Fernando C Ortiz,Juan A Orellana
Frontiers in cell and developmental biology (2024): 1422978-1422978
Methods in molecular biology (Clifton, N.J.) (2024): 135-145
Journal of neurochemistryno. 6 (2024): 1045-1059
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