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个人简介
Juan M. Zapata has a long trajectory in the study of B lymphocyte physiology and pathology, with a main focus on the role of TNFR and TRAF proteins in the regulation of B cell development, differentiation and function. His laboratory is actively involved in the study of B cell neoplasia, particularly chronic lymphocytic leukemia, developing and characterizing new mouse models of B cell malignancies with preclinical interest. His group also works in the identification and preclinical testing of new chemotherapeutic drugs and immunomodulatory agents, including the development of bi-functional antibodies, antibody-drug-complexes (ADC) and in the development of 4th generation CAR T and NK cells.
He obtained his PhD at the “Severo Ochoa” Molecular Biology Center (CBMSO, Madrid) in 1992 and got postdoctoral training at the Immunology Department of the Hospital de la Princesa (1992-1995, Madrid) and at the Burnham Institute (currently Sanford-Burnham-Prebys Medical Discovery Institute (1995-2001, La Jolla, CA)), where he was promoted to Research Assistant Professor (2001-2007). He obtained a tenure track teaching position at department of Molecular Biology of the Autonomous University of Madrid (UAM) in 2007 and in 2009 he got a CSIC tenure scientist position at “Alberto Sols” Biomedical Research Institute (IIBm). He is the head of the Immunity, Immunopathology and Emergent Therapies Group and the principal investigator of the preclinical models and emergent therapies unit. Since 2013 until 2021, he served as the Director of the Department of Metabolism and Cell Signaling at IIBm. JMZ has also been Honorary Professor at the Department of Biochemistry of the Autonomous University of Madrid School of Medicine and member of the PhD Program in Molecular Biosciences committee of UAM (2016-2021).
Juan M. Zapata has authored 81 scientific publications, 4 patents (WO20100324267, WO2014191578, WO2015044491, EP22382700.7), and holds an H-index of 41.
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Javier Glez-Vaz,Arantza Azpilikueta,María C. Ochoa,Irene Olivera, Gabriel Gomis, Asunta Cirella,Carlos Luri‐Rey,Maite Álvarez,Sergio Ciordia,Pedro Berraondo,Álvaro Teijeira, Fernando J. Corrales,
Microorganismsno. 6 (2023): 1548-1548
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Biophysical Journalno. 3 (2022): 390a-390a
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