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个人简介
Juan C. Sáez studies the regulation and function of membrane channels (gap junction channels and hemichannels) composed of proteins called connexins or pannexins. The studies are conducted under physiological and pathophysiological conditions using exogenous expression systems or in primary cells of the nervous or immune system.
During the last decade, he has contributed to understand the involvement of these in the inflammatory response. Since opening of hemichannels is directly involved in the development of inflammatory responses that underlie tissue dysfunction he is searching for potent and selective blockers that could be used as therapeutic agents in diverse chronic diseases with an important inflammatory component.
During the last decade, he has contributed to understand the involvement of these in the inflammatory response. Since opening of hemichannels is directly involved in the development of inflammatory responses that underlie tissue dysfunction he is searching for potent and selective blockers that could be used as therapeutic agents in diverse chronic diseases with an important inflammatory component.
研究兴趣
论文共 296 篇作者统计合作学者相似作者
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Gonzalo I. Gómez, Tanhia F. Alvear, Daniela A. Roa, Arantza Farias-Pasten, Sergio A. Vergara, Luis A. Mellado, Claudio J. Martinez-Araya, Juan Prieto-Villalobos,Claudia García-Rodríguez, Natalia Sánchez,Juan C. Sáez,Fernando C. Ortíz,
Biological Researchno. 1 (2024): 1-19
Verónica Abudara,Ricardo C. Araneda, Luis Barrio,Viviana M. Berthoud,Jorge E. Contreras,Eliseo Eugenín,Juan Lerma,Juan A. Orellana, Nicolás Palacios-Prado, Martha Pérez-Armendariz,Mauricio A. Retamal,Juan C. Sáez
Neuroscience (2024)
Veronica Abudara, Ricardo C. Araneda, Luis Barrio, Viviana M. Berthoud,Jorge E. Contreras,Eliseo Eugenin,Juan Lerma,Juan A. Orellana,Nicolas Palacios-Prado, Elia Martha Perez-Armendariz,Mauricio A. Retamal,Juan C. Saez
NEUROSCIENCE (2024): 81-84
JOURNAL OF NEUROCHEMISTRY (2024)
Proceedings of the National Academy of Sciences of the United States of Americano. 31 (2023): e2307898120-e2307898120
Luis A. Cea, Walter Vasquez, Romina Hernandez-Salinas,Alejandra Z. Vielma,Mario Castillo-Ruiz,Victoria Velarde,Magdiel Salgado,Juan C. Saez
BIOMOLECULESno. 4 (2023): 708-708
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