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Research interests
The research interests of this investigator are within the frame of two major topics: (i) structural characterization of biological macromolecular assemblies, and (ii) nuclear proteins. The first includes both biochemical and biophysical approaches to the study of protein-protein and protein-DNA interactions. Chromatin is the particular biological system presently being analyzed in this area. Current research includes studies on histone-histone interactions, and on histone-DNA interactions at the nucleosome level and at the higher order structure of chromatin. Special attention is being paid to the influence on these interactions of biologically significant chemical modifications, both at the histone and at the DNA level (acetylation, phosphorylation, methylation).
The interest in the second topic comes from the fact that histones are not the only proteins that are associated with DNA inside the cell nucleus. These latter proteins may be, depending on the organism, displaced by a complex broad spectrum of other more basic proteins during the differentiation process of spermatogenesis. These spermatogenic proteins exhibit neither the compositional homogeneity nor the structural features of the typical histones. The current research in this area is centered on the chemistry of such proteins (characterization, sequencing) as well as on the molecular mechanisms involved in the regulation of the genes encoding these proteins.
The research interests of this investigator are within the frame of two major topics: (i) structural characterization of biological macromolecular assemblies, and (ii) nuclear proteins. The first includes both biochemical and biophysical approaches to the study of protein-protein and protein-DNA interactions. Chromatin is the particular biological system presently being analyzed in this area. Current research includes studies on histone-histone interactions, and on histone-DNA interactions at the nucleosome level and at the higher order structure of chromatin. Special attention is being paid to the influence on these interactions of biologically significant chemical modifications, both at the histone and at the DNA level (acetylation, phosphorylation, methylation).
The interest in the second topic comes from the fact that histones are not the only proteins that are associated with DNA inside the cell nucleus. These latter proteins may be, depending on the organism, displaced by a complex broad spectrum of other more basic proteins during the differentiation process of spermatogenesis. These spermatogenic proteins exhibit neither the compositional homogeneity nor the structural features of the typical histones. The current research in this area is centered on the chemistry of such proteins (characterization, sequencing) as well as on the molecular mechanisms involved in the regulation of the genes encoding these proteins.
Research Interests
Papers共 507 篇Author StatisticsCo-AuthorSimilar Experts
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NUCLEIC ACIDS RESEARCHno. 7 (2024): 3636-3653
Juan Ausió, Alistair Knox,Bo-Hyun Kim, Elaine Humphrey,Brent Gowen,Naoki Minamino,Patrick von Aderkas
Biochemistry and cell biology = Biochimie et biologie cellulaireno. 3 (2024): 285-290
Melissa R Leyden, Peter Michalik, Luciana Baruffaldi, Susheen Mahmood, Ladan Kalani, Donald F Hunt, Jose Maria Eirin-Lopez,Maydianne C B Andrade,Jeffrey Shabanowitz,Juan Ausió
bioRxiv : the preprint server for biology (2024)
Melissa R Leyden,Brent Gowen,Rodrigo Gonzalez-Romero,Jose Maria Eirin-Lopez,Bo-Hyun Kim,Fumio Hayashi, Jay McCartney, Patrick C Zhang,Miyoko Kubo-Irie,Jeffrey Shabanowitz,Donald F Hunt,Patrick Ferree,
Biochemistry and cell biology = Biochimie et biologie cellulaireno. 3 (2024): 238-251
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2023): S131-S132
EUROPEAN NEUROPSYCHOPHARMACOLOGY (2023): S248-S249
Psychiatric geneticsno. 6 (2023): 213-232
László Imre,Péter Nánási, Ibtissem Benhamza,Kata Nóra Enyedi,Gábor Mocsár,Rosevalentine Bosire,Éva Hegedüs,Erfaneh Firouzi Niaki,Ágota Csóti, Zsuzsanna Darula,Éva Csősz,Szilárd Póliska,
biorxiv(2023)
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