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John is a pioneer in the translation of basic science theory into clinical trials for lethal prostate cancer. Decades ago, he began doing science that no one else was attempting: finding ways to exploit the body’s process of apoptosis (basically, cellular suicide) as a means of killing metastatic prostate cancer.
In pioneering studies with Coffey, he showed that resistance to androgen deprivation occurs because of clonal selection: that androgen-resistant cells continue to grow, unfazed by hormonal therapy, and eventually overtake the hormone-sensitive cells. In subsequent studies, he and colleagues defined the mechanism by which androgen deprivation kills cells through apoptosis, and then provided evidence for a metastasis suppressor gene.
In pioneering studies with Coffey, he showed that resistance to androgen deprivation occurs because of clonal selection: that androgen-resistant cells continue to grow, unfazed by hormonal therapy, and eventually overtake the hormone-sensitive cells. In subsequent studies, he and colleagues defined the mechanism by which androgen deprivation kills cells through apoptosis, and then provided evidence for a metastasis suppressor gene.
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Papers共 340 篇Author StatisticsCo-AuthorSimilar Experts
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PROSTATEno. 1 (2024): 100-110
Sumer Jasmine, Adel Mandl,Timothy E G Krueger,Susan L Dalrymple,Lizamma Antony, Jennifer Dias,Cassandra A Celatka, Amy E Tapper,Maria Kleppe,Mayuko Kanayama,Yuezhou Jing,Valentina Speranzini,
The Prostateno. 10 (2024): 909-921
A Mandl, S Jasmine, TEG Krueger,R Kumar,IM Coleman,SL Dalrymple,L Antony, DM Rosen, Y Jing,B Hanratty,RA Patel,L Jin-Yih,
biorxiv(2024)
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