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Her PhD focussed on investigating the mechanism of action of mycolactone, a cytotoxic lipid responsible for the pathogenesis of the neglected tropical disease, Buruli ulcer. Her work contributed to the identification of Sec61, a major component of the endoplasmic reticulum protein translocation machinery, as the molecular target of mycolactone. She also discovered a potential role for dysregulated haemostasis in Buruli ulcer pathogenesis and unravelled the mechanistic linkage between blockade of protein translocation by mycolactone and its cytotoxic function.Her attention switched to immune cells when she moved to the Kennedy to work with Richard Williams. Specifically she is seeking ways to restore the imbalance of immune signals in Rheumatoid Arthritis between the pathogenic Th17 cells and regulatory Tregs. Utilising the knowledge and techniques gained during her PhD, including CRISPR-Cas9 gene-editing, she will be taking a closer look at an immunomodulatory pathway known as the integrated stress response in order to understand its role in T-cell metabolism and the development of specific T-cell subsets. Joy sees lots of potential for collaboration in the way the Kennedy is set up and is also open to collaboration outside of the Kennedy.
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Journal of Autoimmunity (2023): 103031-103031
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biorxiv(2022)
semanticscholar(2021)
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medRxiv (2021)
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