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Our lab aims to achieve a quantitative, comprehensive understanding of cellular metabolism. Our motivation for studying metabolism is two-fold. From a basic science perspective, the molecular connections involved in metabolism are the best understood of any major biochemical network. Accordingly, metabolism provides a unique opportunity for quantitative analysis. From a practical perspective, derangements of metabolism are a major cause of disease, and small molecules that inhibit metabolism are the basis of many important pharmaceuticals. Accordingly, systems-level analysis of metabolism is likely to yield discoveries of medical significance.
A major barrier to understanding metabolism has been lack of appropriate tools. Our lab has developed methods for measuring a wide range of cellular metabolites using state-of-the-art mass spectrometry technology. We have used these tools to discover a novel metabolite involved in the pathogenesis of cancer (Dang et al., 2009). We have innovated approaches to quantitating metabolic fluxes by interpreting isotope-labeling data within a rigorous chemical-kinetic framework.
A major barrier to understanding metabolism has been lack of appropriate tools. Our lab has developed methods for measuring a wide range of cellular metabolites using state-of-the-art mass spectrometry technology. We have used these tools to discover a novel metabolite involved in the pathogenesis of cancer (Dang et al., 2009). We have innovated approaches to quantitating metabolic fluxes by interpreting isotope-labeling data within a rigorous chemical-kinetic framework.
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Kahealani Uehara,Won Dong Lee,Megan Stefkovich, Dipsikha Biswas,Dominic Santoleri,Anna E Garcia Whitlock, William J Quinn Iii, Talia N Coopersmith,Kate Townsend Creasy,Daniel J Rader,Kei Sakamoto,Joshua D Rabinowitz,
The Journal of clinical investigation (2024)
CELL METABOLISMno. 1 (2024): 103-115.e4
bioRxiv : the preprint server for biology (2024)
NATURE CHEMICAL BIOLOGY (2024)
Nature Neurosciencepp.1-13, (2024)
Katrin I Andreasson,Edward N Wilson,Congcong Wang, Matthew Xin,Maharshi Panchal,Joshua D Rabinowitz,Paras S Minhas,Michelle S Swarovski,Javier A Ramos Benitez, Aarooran S Durairaj,Aisling Chaney, Chinyere A Iweka,
biorxiv(2024)
Sarah Cherkaoui,Lifeng Yang,Matthew McBride, Christina S Turn,Wenyun Lu, Caroline Eigenmann,George E Allen,Olesya O Panasenko, Lu Zhang,Annette Vu,Kangning Liu,Yimei Li,
bioRxiv : the preprint server for biology (2024)
Yihui Shen,Hoang V. Dinh,Edward R. Cruz,Zihong Chen,Caroline R. Bartman,Tianxia Xiao,Catherine M. Call, Rolf-Peter Ryseck,Jimmy Pratas,Daniel Weilandt, Heide Baron, Arjuna Subramanian,
Nature Chemical Biologypp.1-10, (2024)
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