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One focus of the lab is on Kidney injury molecule-1 which is markedly upregulated in renal cell carcinoma and other conditions where the kidney proximal epithelial cell is dedifferentiated. We are studying the functional role of this protein and its role as a urinary biomarker for renal cell carcinoma and renal epithelial cell injury. Another focus is on phospholipase A2 (PLA2) and the role of this family of enzymes on carcinogenesis, acute tissue injury, apoptosis, signal transduction and transcriptional regulation. We have created a cPLA2 null mouse and are studying the effects of absence of this gene on bowel cancer development in mice carrying the Min mutation as well as angiogenesis and tumor growth in the cPLA2 -/- mouse . Studies are carried to understand how phospholipases A2 contribute to apoptosis, to evaluate the importance of kinases such as the stress-activated MAP protein kinases, and the proteins interacting with cPLA2 to potentiate cell death, and to identify and characterize transcription factors that play important roles in the cell cycle. We have isolated a nuclear protein that interacts with the cytosolic 85 kDa cPLA2 and potentiates apoptosis. Gene therapy approaches with adenovirus are being used.
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Lipika Samal,John L Kilgallon,Stuart Lipsitz,Heather J Baer,Allison McCoy,Michael Gannon, Sarah Noonan, Ryan Dunk, Sarah W Chen, Weng Ian Chay, Richard Fay,Pamela M Garabedian,
JAMA internal medicineno. 5 (2024): 484-492
Bryan A Nerger,Sumit Sinha,Nathan N Lee, Maria Cheriyan,Pascal Bertsch, Christopher P Johnson, L Mahadevan,Joseph V Bonventre,David J Mooney
Advanced materials (Deerfield Beach, Fla.)no. 14 (2024): e2308325-e2308325
American journal of physiology. Renal physiologyno. 3 (2024): F326-F337
Journal of clinical oncology : official journal of the American Society of Clinical Oncologypp.JCO2300699-JCO2300699, (2024)
FRONTIERS IN PEDIATRICS (2023): 1038206-1038206
Journal of the American Society of Nephrologyno. 11S (2023): 722-722
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