Integrated the bioinformatics and molecular biology techniques to study the molecular mechanism of protein synthesis and explored the association between SNPs and disease. Moreover, I try to translate these technologies into clinical application to achieve the goal of precision medicine. Followings are the major research topics: 1. Explored the functional role of ribosomal protein in regulating the specific protein synthesis 2. Using the technology of ribosome profiling to dissect the functional role of IRES in translational regulation. 3. To discover the early biomarker of colorectal cancer and the development process from polyps to cancer. 4. Established the DNA big data analysis platform to dissect the correlation of SNP and disease.