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个人简介
My laboratory’s mission is to understand the programmed cell death pathway (apoptosis) with the goal of gaining fundamental insight into how cellular homeostasis is controlled. Using the hematopoietic and other systems as models, we seek to define the roles of individual BCL2 family members and to comprehend their normal regulation. Understanding this basic biology is important for human diseases such as cancer because the programmed cell death pathway is commonly corrupted in malignant cells. By better understanding how the cell death machinery is regulated we can identify important signaling nodes that can be targeted to improve cancer responses to therapy. The availability of drugs which can modulate the cell death machinery, including BH3-mimetic agents, has the potential to revolutionize cancer therapy. Therefore, we seek to identify additional strategies to incorporate these therapeutic agents into cancer treatments with a focus on lymphoid and myeloid leukemia using state of the art cellular and genetic models.
研究兴趣
论文共 125 篇作者统计合作学者相似作者
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Breast Cancer Researchno. 1 (2024): 1-2
Stephanie M Rockfield,Meghan E Turnis, Ricardo Rodriguez-Enriquez,Madhavi Bathina, Seng Kah Ng, Nathan Kurtz, Nathalie Becerra Mora,Stephane Pelletier,Camenzind G Robinson,Peter Vogel,Joseph T Opferman
bioRxiv (Cold Spring Harbor Laboratory)no. 6 (2024)
Stephanie M. Rock,Meghan E. Turnis, Ricardo Rodriguez-Enriquez,Madhavi Bathina, Seng Kah Ng, Nathan Kurtz, Nathalie Becerra Mora,Stephane Pelletier,Camenzind G. Robinson,Peter Vogel,Joseph Opferman
LIFE SCIENCE ALLIANCEno. 6 (2024)
Tristen Wright,Meghan E Turnis,Christy R Grace, Xiao Li, Lauren A Brakefield, Yong-Dong Wang, Haiyan Xu, Ewa Kaminska, Leslie K Climer, Tresor O Mukiza, Chi-Lun Chang,Tudor Moldoveanu,
Molecular cell (2024)
Clinical Lymphoma Myeloma and Leukemia (2023): S153
Yvan Campos,Ricardo Rodriguez-Enriquez,Gustavo Palacios,Diantha van de Vlekkert,Xiaohui Qiu, Jayce Weesner,Elida Gomero,Jeroen Demmers, Tulio E. Bertorini,Joseph T. Opferman,Gerard Grosveld,Alessandra d’Azzo
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Cell reportsno. 10 (2023): 113176
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JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2023)
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Cell death and differentiationno. 5 (2023): 1097-1154
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