基本信息
浏览量:468
职业迁徙
个人简介
It was long believed the sequence of genes in a genome was all that was needed to understand that organism’s biology. Recently, scientists have realized there’s another level of control: the epigenome. The epigenome is made up of chemicals that dot the DNA, dictating when, where and at what levels genes are expressed. But how these epigenomic tags affect biology, health and disease is still poorly understood. To decrypt the information they contain, researchers still need to answer basic questions about this extra genetic code.
Ecker first became entranced by the epigenome while he was studying Arabidopsis thaliana, a small flowering plant used for basic plant biology research. He and his colleagues wanted to know how many Arabidopsis genes were controlled by DNA methylation—one form of chemical markers that stud genes to affect how genes are expressed. In the process of the research, Ecker realized there was no good way to get a snapshot of all the methylation marks in a cell, so he created a method called MethylC-Seq to map epigenetic tags in any organism. Ecker has now applied MethylC-Seq to questions about epigenetics that span many fields, in particular, the human brain. He was the first to show that the epigenome is highly dynamic in brain cells during the transition from birth to adulthood. Now, he is charting the epigenetic differences between brain cell types to better understand disorders such as schizophrenia and Alzheimer’s disease.
Ecker first became entranced by the epigenome while he was studying Arabidopsis thaliana, a small flowering plant used for basic plant biology research. He and his colleagues wanted to know how many Arabidopsis genes were controlled by DNA methylation—one form of chemical markers that stud genes to affect how genes are expressed. In the process of the research, Ecker realized there was no good way to get a snapshot of all the methylation marks in a cell, so he created a method called MethylC-Seq to map epigenetic tags in any organism. Ecker has now applied MethylC-Seq to questions about epigenetics that span many fields, in particular, the human brain. He was the first to show that the epigenome is highly dynamic in brain cells during the transition from birth to adulthood. Now, he is charting the epigenetic differences between brain cell types to better understand disorders such as schizophrenia and Alzheimer’s disease.
研究兴趣
论文共 509 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Jiyun Zhou,Chongyuan Luo,Hanqing Liu, Matthew G Heffel, Richard E Straub,Joel E Kleinman,Thomas M Hyde,Joseph R Ecker,Daniel R Weinberger,Shizhong Han
bioRxiv : the preprint server for biology (2024)
Min Cao,Matthieu Pierre Platre,Huei-Hsuan Tsai,Ling Zhang,Tatsuya Nobori,Laia Armengot, Yintong Chen,Wenrong He, Lukas Brent,Nuria S. Coll,Joseph R. Ecker,Niko Geldner,
Natureno. 7996 (2024): 750-759
Natureno. 7996 (2024): 1-1
Stephen Gonzalez,Joseph Swift, Adi Yaaran,Jiaying Xu, Charlotte Miller,Natanella Illouz-Eliaz,Joseph R. Nery, Wolfgang Busch, Yotam Zait,Joseph R. Ecker
biorxiv(2024)
Bang-An Wang,Jeffrey R. Jones,Jingtian Zhou,Wei Tian, Yue Wu,Wenliang Wang,Peter Berube,Anna Bartlett,Rosa Castanon,Joseph R. Nery,Huaming Chen, Mia Kenworthy,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
biorxiv(2023)
Shelly A. Wanamaker,Renee M. Garza,Andrew MacWilliams,Joseph R. Nery,Anna Bartlett,Rosa Castanon, Adeline Goubil, Joseph Feeney,Ronan O'Malley,Shao-shan C. Huang,Zhuzhu Z. Zhang,Mary Galli,
NATURE METHODSno. 3 (2023): 469-469
Nature Communicationsno. 1 (2023)
引用1浏览0引用
1
0
bioRxiv : the preprint server for biology (2023)
Science (New York, N.Y.)no. 6667 (2023): eadf5357-eadf5357
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn