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He worked for the next seven years at small companies in Detroit, developing adhesives, metal polishing compounds, lubricants and other specialty chemical formulations used in the automobile industry. While working in Detroit after receiving his bachelor's degree, Katz and several colleagues rented a room in a Detroit office building and used it as a laboratory. They carried out independent research from 1932 through 1939, trying to cure tuberculosis by finding a substance that could dissolve the fatty outer coating of the TB bacillus so that it would be vulnerable to being destroyed by a drug. He and a Detroit colleague published two papers on studies with the bacterium Mycobacterium smegmatis, a fast-growing and non-pathogenic bacillus with similar physical properties to the tuberculosis bacillus.
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