基本信息
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Career Trajectory
Bio
Degree in Chemistry (University of Oviedo, 2001). Bachelor's Thesis (Organic Synthesis, Oviedo, 2002). Master’s in biotechnology (ALITER, International Business School, Madrid, 2004). CITIUS Grant (GlaxoSmithKline, DDW Research Center, Tres Cantos, 2005). Doctorate in Medicinal Chemistry (Universidad San Pablo CEU, Madrid, 2011). Associate Professor (Universidad San Pablo CEU, 2010-2015) and Adjunct Professor at the same University (2015-present).
Thanks to the CITIUS program, I was able to continue improving my experience in laboratory techniques after graduation. During that time, I worked at GlaxoSmithKline in the DDW Research Center (Laboratory of Medical Chemistry) on the "Plasmodium Falciparum Enoyl-ACP Reductase" project. After that scholarship, I joined the CEU University of San Pablo in 2006 for doctoral studies under the direction of professors Ana Ramos and Beatriz de Pascual-Teresa (2011). The main objective in this period was the design, synthesis and evaluation of matrix metalloproteinase (MMP) inhibitors. I started my career at UPS-CEU as associate professor in 2010 and I have been an adjunct professor since 2015, after being accredited by ANECA for that position. In 2022 I obtained a positive requirement to belong to the Corps of University Senior Lecturers.
I am the author or co-author of 23 scientific publications and two patents. As part of my teaching dedication, I supervise end-of-studies projects and end-of-master degrees, of national students and students from the Erasmus program and / or international bilateral agreements from the United Kingdom, Poland, Italy, etc. I am co-director of a thesis in medical chemistry. I was awarded in teaching innovation by the San Pablo CEU University in 2012. I also carried out two postdoctoral research stays, of 3 months each, in foreign universities. During the first I worked in the MAREX project in the synthesis of derivatives of marine natural products under the supervision of Professor Danijel Kikelj (University of Ljubljana, Slovenia). In the second short stay I worked on 3D-QSAR models for a series of MMP inhibitors in the laboratory of Krzysztof Jóźwiak (Medical University of Lublin, Poland).
As part of the research group of Beatriz de Pascual-Teresa and Ana Ramos, I have experience in organic synthesis and drug design, focusing my research on the design and synthesis of cancer-related targets such as MMP, CK2, HDAC and Adrenomedullin. I received the Royal National Academy of Pharmacy Award for work done on MMPs in 2011.
Another field of expertise is the design and synthesis of molecules that cross the blood-brain barrier and inhibit the protein tyrosine-phosphatase Z1 receptor (PTPRZ1). Inhibitors of this receptor could be used in the treatment of alcohol abuse and Parkinson's disease.
An additional goal that I have focused on is the synthesis of compounds capable of inducing hypothermia and their ability to prevent or delay eye damage after an explosion. This research has been funded by the US Department of Defense. (Scholarship: W81XWH-14-1-0463 MR130239)
Research Interests
Papers共 37 篇Author StatisticsCo-AuthorSimilar Experts
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Biomedicinesno. 5 (2023): 1318-1318
NEUROPHARMACOLOGY (2023)
Frontiers in pharmacology (2023): 1252184-1252184
Neuropharmacology (2023): 109438-109438
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International Journal of Molecular Sciencesno. 6646 (2021): 6646
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