基本信息
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个人简介
I hold a degree in Biology from the University of Santiago de Compostela (USC). I carried out my doctoral thesis at the Department of Biochemistry and Molecular Biology, University of Santiago under the supervision of Professor Javier Benavente. In January 1994 I began a postdoctoral fellow at Oxford (UK) in the laboratory of Dr. Polly Roy, working with Bluetongue Virus (BTV). In September 1996 I was awarded a “Contrato de Reincorporación de Doctores y Tecnólogos del Ministerio de Educación” to return to the University of Santiago.
Research
Our group has been dedicated to study the molecular biology of avian reoviruses, as well as the molecular mechanisms that regulate their interactions with the host cell. Our research is currently focused on the following objectives:
1-Structure-function characterization of viral proteins. In our laboratory we have identified and characterized the activity of most proteins of reovirus S1133. We have already obtained the crystal structures of proteins sigma-C and sigma-A. Currently, we are trying to get crystals of other different viral proteins together with the whole virus and core-like particles.
2-Avian reovirus morphogenesis. We have reported that muNS is the viral protein responsible for the formation of the viral factories where viral morphogenesis occurs. We are now extending these studies to determine the precise mechanisms which control the selective recruitment of both proteins and genome segments to the factories, for the formation of progeny virus.
3- Virus-cell interactions. Our group has demonstrated that avian reoviruses are resistant to the antiviral effects of interferon. Our results showed that sigmaA plays a fundamental role in the resistance of avian reoviruses to the antiviral effects of interferon.
4- Virus-based biotechnological applications. We have developed and patented the IC-tagging technology platform that allows by the directed relocation of the tagged proteins into dense cytoplasmic inclusions (either in the nucleus or in the cytoplasm), detection of protein‐protein interactions (either in the nucleus or in the cytoplasm of living cells), production of in vivo micro/nanoparticles containing different proteins for their use as polyantigenic vaccines, delivery of therapeutic proteins and production of immobilized enzymes for industrial use. The system has produced two patents that were extended to Europe and USA, and licensed to a company external to the USC.
5- We keep close colaboration with several groups based in the CIQUS (Mascareñas, Megía, Eugenio Vázquez/Miguel Vázquez), on the development of bio-active organic molecules.
研究兴趣
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CHEMICAL SCIENCEno. 48 (2023): 14082-14091
Water research (2022): 117861-117861
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作者统计
#Papers: 77
#Citation: 2350
H-Index: 29
G-Index: 46
Sociability: 5
Diversity: 0
Activity: 1
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