Pimiento's clinical interest is in malignancies of the upper gastrointestinal tract, including esophageal, gastric, pancreatic, colorectal and liver cancers. His practice is focused on minimally invasive approaches including laparoscopic and robotic surgery. Dr. Pimiento has helped develop a comprehensive robotic program for the management of upper gastrointestinal and pancreatic tumors, making Moffitt Cancer Center one of the leaders in this field in the country. Dr. Pimiento also is the associate program director for the Complex Surgical Oncology Fellowship at Moffitt.