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个人简介
José V. Castell. PhD in Biochemistry and MD in Medical Biochemistry, Graduate in Pharmacy. Postdoctoral at the ETH-Zürich and Max-Planck Institut, Göttingen. Invited professor at the Biochemisches Institut de Univesität Freiburg. Emeritus Professor of the Chair of Medical Biochemistry and Molecular Biology at the Faculty of Medicine of Valencia where he also reads a postgraduate course on Molecular Toxicology and Clinical Immunology. Head of the Unit of Experimental Hepatology at the Research Institute of the University Hospital La Fe (Valencia). Ex-Director of the Medical Research Center of the University Hospital La Fe (Valencia).
In 1990, Professor Castell was given the International Award of the European Federation of Pharmaceutical Industries (Heidelberg 1990) for the development of cultured human hepatocytes to investigate the hepatotoxic risk of new drugs to man.
His major research interests include: in vitro drug metabolism and hepatotoxicity, drug induced liver injury in clinics, cell reprogramming to hepatocytes, cell therapy with human hepatocytes and PSC-derived hepatocytes. He has authored 410 papers, including scientific articles published in relevant international journals, book chapters and several reviews.
His current research interest involve the use of metabolomics to assess drug hepatotoxicity in the clinics and in vitro (drug development, metabolism and toxicity).
Former member of the Scientific Advisory Committee of the European Center for Validation of Alternative Methods (ECVAM), Scientific Committee of INVITOX, and Scientific Committee ILSI.
Prof. Castell has been actively involved in over 25 EU research projects; and has served as coordinator in 3 of them.
研究兴趣
论文共 458 篇作者统计合作学者相似作者
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APPLIED SPECTROSCOPY REVIEWSno. 4 (2024): 578-599
ANALYTICA CHIMICA ACTA (2024): 342052-342052
Ernesto López-Pascual,Ivan Rienda,Judith Perez-Rojas, Anna Rapisarda,Guillem Garcia-Llorens,Ramiro Jover,José V Castell
International journal of molecular sciencesno. 10 (2024)
Ernesto López-Pascual,Ivan Rienda,Judith Perez-Rojas, Anna Rapisarda,Guillem Garcia-Llorens,Ramiro Jover,José V. Castell
International Journal of Molecular Sciencesno. 10 (2024)
Rita Ortega-Vallbona, Rebeca Mendez,Laia Tolosa,Sylvia E. Escher,Jose Castell,Rafael Gozalbes,Eva Serrano-Candelas
TOXICOLOGY (2024): 153764-153764
Ivan Rienda,Marta Moreno-Torres,Erika Moro,Judith Perez-Rojas,Eugenia Pareja,Alvaro Perez-Rubio, Nuria Peris,Jose Angel Diez Ares, Ramon Trullenque,Ramiro Jover,Bernhard Lendl,Julia Kuligowski,
MICROCHEMICAL JOURNAL (2024)
Ernesto López-Pascual,Ivan Rienda,Judith Perez-Rojas, Anna Rapisarda,Guillem Garcia-Llorens,Ramiro Jover,José V. Castell
International Journal of Molecular Sciencesno. 10 (2024): 5203
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCESno. 5 (2024): 3003
Gert Vanmarcke,Jonathan Sai-Hong Chui,Axelle Cooreman,Kristof De Vos, Lana Cleuren,Rob Van Rossom,Guillem García-Llorens,Teresa Izuel Idoype,Ruben Boon, Manoj Kumar Gautam,José V Castell,Pieter Annaert,
STEM CELLSno. 11 (2023): 1076-1088
Archives of Toxicologyno. 6 (2023): 1723-1738
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