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职业迁徙
个人简介
1989-1993. I started scientific career in 1989 with a fellowship for Training of Research Staff (FPI) that allowed me to do the Doctoral Thesis under the direction of Prof. Antonio Canedo at the USC (Santiago de Compostela-Spain). My Thesis dealt with descending motor systems in anesthetized cats using classical electrophysiological techniques. We showed the strong connection between the motor cortex and the dorsal column nuclei. I also collaborated with the group of Prof. Carlos Diéguez in the regulation of the secretion of growth hormone by retinoic acid.
1993-1994. A fellowship from the USC (3 months) allowed me to learn the basics of the "patch-clamp" technique in the laboratory of Professor JD Vincent/PM Lledo (Institut Alfred Fessard of Paris, CNRS). I returned to the USC where I settled the first patch-clamp laboratory in Galicia, although this stage lasted only 6 months (post-doctoral fellowship from the USC), this was enough to study the modulation of sodium channels by caprylic acid in neuroglioma cells and to publish an article.
1994-1996. In April 1994 I started a postdoctoral stay in Prof. David A. Brown`s group (University College London. UCL) that would last two and a half years. Initially I financed myself with a post-doctoral fellowship from the Xunta de Galicia. Later I got a supplement from the English Medical Research Council and from the pharmaceutical company Dupont-Merck. Finally, I got a competitive project from the Wellcome Trust Foundation. The most relevant work of this period was the systematic study of Linopirdine, a relatively selective blocker for the M current and that contributed to the discovery of the KCNQ family of potassium channels.
1996-2015. In December 1995, I obtained a Lecturer position at the University of Vigo, which became Interim Holder in April 1998 and Associate Professor in April 2000. We studied the ionic basis for the maintenance of resting potential in neurons of the superior cervical ganglion in culture. Later, we investigated the role of the persistent sodium current in subthreshold oscillations. In 2008, we discovered for the first time the presence of two-pore domain channels (K2P) in neurons of the autonomic nervous system, initially in the superior cervical ganglion and later in the nodose ganglion. During this time in Vigo, I have collaborated with different Spanish groups such as Professor Roberto Gallego, Dr. Andrés Morales, doctors Diego Álvarez and Teresa Giráldez or Dr. Álvaro Villarroel. Many of these collaborations have been financed by a CONSOLIDER project, but my group has been financed for 15 years by the different ministries.
2016-present. In February 2016, our laboratory moved from the Faculty of Biology to the Biomedical Research Centre (CINBIO) located on the UVIGO campus. This centre has obtained the qualification of “Singular Research Centre” from the Xunta de Galicia although it still belongs to the UVIGO. Here we initiated a new line of research dealing with two-pore domain potassium channels in the parasympathetic intracardiac ganglion and initiated an international collaboration with the group of Prof. Alistair Mathie from the University of Kent.
研究兴趣
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IBRO Neuroscience Reports (2023): S218-S219
IBRO Neuroscience Reports (2023): S253-S253
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