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Bio
I completed medical school and Internal Medicine residency in Chile, and then came to the US where I finished my training in Infectious Diseases at the University of Texas Medical School at Houston and the MD Anderson Cancer Center. My main areas of interest are the clinical and molecular aspects of bacterial antimicrobial resistance, with special emphasis on Gram-positive organisms. For this reason, I also spent a year as a postdoctoral research fellow in the Laboratory for Antimicrobial Research at the University of Texas Medical School, directed by Dr. Cesar A. Arias, and then continued my training as a clinician scientist with an Advanced Infectious Diseases Fellowship. During this time, my main focus of research was to help decipher the molecular mechanisms of daptomycin (DAP) resistance in enterococci. Specifically, I had the opportunity of leading the translational aspects of our project, through which we were able to find genetic determinants present in a subset of DAP-susceptible enterococcal isolates that decrease the activity of the antibiotic and confer a high-risk for clinical failure in patients with invasive enterococcal infections. Back in my home country, Chile, I established a research group dedicated to the study of multidrug-resistant organisms in Latin America, including the study of their molecular epidemiology, mechanisms of resistance and clinical outcomes of patients infected with resistant bacteria. In addition, I have had the opportunity of participating in several joint projects with the US CDC in order to improve our understanding of the role of bacterial colonization with drug resistant pathogens in the dissemination of antimicrobial resistance and to establish the role of the environment, water sources and food as a source of antimicrobial resistant bacteria.
Research Interests
Papers共 167 篇Author StatisticsCo-AuthorSimilar Experts
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crossref(2024)
Stephanie L. Egge, Samie A. Rizvi,Shelby R. Simar, Manuel Alcalde, Jose R.W. Martinez,Blake M. Hanson,An Q. Dinh,Rodrigo P. Baptista,Truc T. Tran,Samuel A. Shelburne,Jose M. Munita,Cesar A. Arias,
bioRxiv the preprint server for biology (2024)
Katherine D. Soto,Manuel Alcalde-Rico,Manuel Alcalde-Rico,Manuel Alcalde-Rico,Manuel Alcalde-Rico,Juan A. Ugalde,Juan A. Ugalde,Jorge Olivares-Pacheco,Jorge Olivares-Pacheco, Valeria Quiroz, Valeria Quiroz,Bárbara Brito,
Frontiers in Cellular and Infection Microbiology (2024)
LANCET REGIONAL HEALTH-AMERICAS (2024): 100654-100654
Antimicrobial agents and chemotherapyno. 2 (2024): e0151023-e0151023
Clinical infectious diseases : an official publication of the Infectious Diseases Society of Americano. 2 (2024): 248-258
ANTIMICROBIAL AGENTS AND CHEMOTHERAPYno. 2 (2024)
Katherine D Soto, Manuel Alcalde-Rico,Juan A Ugalde, Jorge Olivares-Pacheco, Valeria Quiroz, Bárbara Brito, Lina M Rivas,José M Munita, Patricia C García, Aniela Wozniak
Frontiers in cellular and infection microbiology (2024): 1410834-1410834
José RW Martínez,Paul J. Planet,Spencer-Sandino Maria,Rivas Lina,Díaz Lorena, Quesille-Villalobos Ana,Riquelme-Neira Roberto,Alcalde-Rico Manuel,Hanson Blake,Lina P Carvajal,Rincón Sandra,Reyes Jinnethe,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Sebastián Higuera-Llantén, María S. Pavlov,Leandro Pio de Sousa,Felipe Vásquez-Ponce, Juan Parás-Silva,Jose RW Martinez,José M. Munita, Aniela Wozniak, Patricia García,Juan A. Ugalde,Felipe Lira,Manuel Alcalde-Rico,
Research Square (Research Square) (2023)
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