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Our work has focused on understanding how these protein assembly machines self-organize and work, how they evolved, and also on targeting them with small molecules, employing interdisciplinary approaches at the CIB and collaborating labs. Our group pioneered protein shape determination with synchrotron SAXS, bead models and genetic algorithms. We have developed fluorescence polarization screening assays for antitumor inhibitors binding to the taxane site of microtubules, as well as fluorescent assays and cell-based methods to screen for GTP-replacing and allosteric antibacterial FtsZ inhibitors.
研究兴趣
论文共 207 篇作者统计合作学者相似作者
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Federico M Ruiz,Sonia Huecas, Alicia Santos-Aledo, Elena A Prim,José M Andreu,Carlos Fernández-Tornero
biorxiv(2022)
biorxiv(2021)
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D-Core
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