基本信息
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Bio
I graduated from the University of Salamanca in 2001 with a degree in Biochemistry and completed my PhD at the Institute of Neuroscience of Castilla y León (INCyL, 2001-2007) in 2007 under the supervision of Dr. Alonso and Dr. Weruaga. My thesis focused on plasticity and neurodegeneration in the olfactory bulb and resulted in 9 publications and a patent. During my first postdoctoral stage ( 2007-2008), I spent 9 months at the laboratory of Dr. Cooper ( King's College of London, UK) studying adult neurogenesis in animal models and human brain samples of Batten's disease. Then ( 2008-2011), I continued my postdoctoral studies at the laboratory of Dr. Saura ( Institute of Neuroscience, Autonoma University of Barcelona), where we demonstrated that environmental stimulation prevents cognitive deficits and increases adult neurogenesis in the hippocampus of a mouse model of Alzheimer's disease (AD). I also analyzed molecular aspects of memory and AD, revealing the role of CRTC1 (CREB-regulated transcription coactivator-1) in controlling transcription associated with memory (two papers in J. Neuroscience). In 2011, I moved to the laboratory of Dr. Malva ( Center for Neuroscience and Cell Biology, University of Coimbra, Portugal). We demonstrated that an acute and systemic inflammatory stimulus induces a long-term decrease in the production of new neurons and interferes with memory. In 2014, I was the principal investigator of a project ( 2014-2015) related to the influence of diet on adult neurogenesis. I also established collaborations and contributed to analyzing the effects of hyperglycemia and a dietetic supplement in adult neurogenesis in an AD mouse model. In 2015, I joined the Achucarro Basque Center for Neuroscience as an Ikerbasque Research Fellow, co-leading research projects with Dr. Sierra to analyze the effects of phagocytic microglia on adult neurogenesis (Journal of Neuroscience). I also led my own research studies on the effects of a balanced and deficient diet on omega-3 (Int. J. Mol Sci. 2022) and the development of image analysis tools (see below). Finally, in 2021, I joined the Neuronal Plasticity and Neurorepair laboratory at the INCyL. Here, I analyze lifestyle factors and disease effects on the brain and study the integration of bone marrow-derived cells in the central nervous system.
TECHNICAL EXPERTISE
I am skilled in behavioral tests, cell culture, small mammal brain surgery, histology, stereology, imaging, transcriptomic and multivariate analysis.
SCIENTIFIC CONTRIBUTION
55 papers, H index: 27, more than 3000 citations (Google Scholar). 2 six-year research periods awarded. I have participated in 15 research projects, leading 5 (2 from the Spanish and 2 from the Portugal governments, and 1 from a private foundation). I have presented around 100 communications ( oral and posters) at national and international congresses and given talks at different institutions. I also organized a workshop at an international congress (Euroglia meeting) and participated in organizing a national neuroscience meeting in Portugal. I have evaluated research projects from Spain, France, a European Consortium, and a United States research foundation. I have been a member of the editorial board of two research journals and reviewed manuscripts for more than 20 journals. I have an extensive network of collaborations, many of which have been consolidated through ongoing or past research projects.
CONTRIBUTION TO SOCIETY
I have developed new freely available tools for image analysis, specifically for studying microglia and adult neurogenesis. I have developed freely available tools for semi-automatic analysis of the organization of the Drosophila's eye (Fleye, Mol. Neurodegener. 2015), microglial process motility (ProMoIJ, Glia 2018), hippocampal stem cell classification (CellShaper, Aging Cell, 2019), volume estimation (VolumestJ, Biorxiv, 2022) and staining analysis (Thresholderer, Front. Cell. Neurosci., 2023).
I am also actively involved in science communication and outreach, co-organizing events such as the Pint of Science festival and giving talks and writing (Investigación y Ciencia 2017 and The Conversation 2020) to a variety of audiences.
MENTORING AND TRAINING YOUNG RESEARCHERS
I have supervised 9 Master's and 5 PhD students and have a track record of working with graduate students and postdoctoral fellows.
OTHER MERITS
At the end of 2021, I received the i3 certificate from the Spanish government that recognizes my research trajectory and in November 2022 I incorporated into the USAL as Associate Professor (Profesor Titular de Universidad).
Research Interests
Papers共 81 篇Author StatisticsCo-AuthorSimilar Experts
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David Perez-Boyero, Carlos Hernandez-Perez,Jorge Valero, Valeria Lorena Cabedo,Jose Ramon Alonso,David Diaz,Eduardo Weruaga
FRONTIERS IN CELLULAR NEUROSCIENCE (2023): 1120836-1120836
Miriam Corraliza-Gomez, Beatriz Bendito, David Sandonis-Camarero, Jorge Mondejar-Duran, Miguel Villa, Marta Poncela,Jorge Valero,Diego Sanchez,Maria D. Ganfornina
Sol Beccari,Virginia Sierra-Torre,Jorge Valero, Marta Pereira-Iglesias, Mikel Garcia-Zaballa,Federico N. Soria,Laura De Las Heras-garcia,Alejandro Carretero-Guillen,Estibaliz Capetillo-Zarate,Maria Domercq,Paloma R. Huguet,David Ramonet,
bioRxiv (Cold Spring Harbor Laboratory) (2023)
Cellsno. 13 (2023)
Pablo G Téllez de Meneses,Laura Pérez-Revuelta,Ángel Canal-Alonso, Carlos Hernández-Pérez, Teresa Cocho,Jorge Valero,Eduardo Weruaga,David Díaz,José R Alonso
Frontiers in neuroanatomy (2023): 1224342
Marta Pereira-Iglesias, Duncan Martinson, Carles Falco,Ainhoa Plaza-Zabala, Joel Maldonado-Teixidó, Alice Louail,Sol Beccari,Jorge Valero,Fernando Garcia-Moreno, Jose A Carrillo,Amanda Sierra
IBRO Neuroscience Reports (2023): S126-S126
Journal of neuroinflammationno. 1 (2023): 1-21
Carla Cavaleiro,Goncalo J. M. Afonso, Paulo J. Oliveira,Jorge Valero,Sandra I. Mota,Elisabete Ferreiro
FRONTIERS IN MOLECULAR NEUROSCIENCE (2023): 1229728-1229728
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