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个人简介
Jorge Pedrosa, born in 1964, holds a degree in Biochemistry and a PhD in Biomedical Sciences.
Jorge Pedrosa is a Full Professor at the School of Medicine (EM) - University of Minho (UM), the EM Vice-Dean for research and a Principal Investigator at the Microbiology and Infection Research Domain at the Life and Health Sciences Research Institute (ICVS) - UM.
In the medical course of the EM, Jorge Pedrosa is the Coordinator of the Curricular Area “Biopathology and Introduction to Therapeutics”, which associates the themes of Pathology, Genetics, Immunology, Microbiology and Pharmacology.
J. Pedrosa Research interests are in the field of Health Sciences-Immunology. He is a member of the Microbiology and Infection Research Line in ICVS and he is particularly interested in the host immune response against infections by highly virulent mycobacteria, namely Mycobacterium ulcerans, the causative agent of the emergent tropical disease Buruli ulcer, and Mycobacterium tuberculosis, the causative agent of tuberculosis. He is using animal models in Biosafety Level 3 laboratories and collaborating with a network of health care institutions in Portugal and in Benin, to both evaluate new strategies aiming at the modulation of the host immune response (e.g. design of new vaccines) and to develop new systems of specific delivery of antimicrobial agents to infected cells.
Jorge Pedrosa has published more than 60 peer-reviewed research articles that have been cited more than 1000 times. He has supervised several PhD-Students and Post-Docs.
His main Research Contributions include:
- First demonstration of a protective role played by neutrophils in the early phase of experimental tuberculosis.
- First isolation from the environment of a pure culture of M. ulcerans, the causative agent of the emergent infectious disease Buruli ulcer, implicating the involvement of aquatic insects in the transmission of this neglected disease.
- Characterization of the host inflammatory response to M. ulcerans;
- First description of an intracellular growth phase for M. ulcerans, as well as of the mechanisms of macrophage-mediated immune control for this pathogen.
研究兴趣
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Carla Correia, Ana Claudia Leite,Alexandra G. Fraga,M. Fernanda Proenca,Jorge Pedrosa,M. Alice Carvalho
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2024): 116297-116297
BIOENGINEERING & TRANSLATIONAL MEDICINEno. 3 (2023)
Marne Azarias Da Silva,Pierre Nioche,Calaiselvy Soudaramourty, Anne Bull-Maurer, Mounira Tiouajni,Dechuan Kong,Ouafa Zghidi-Abouzid,Morgane Picard,Ana Mendes-Frias,Andre Santa-Cruz,Alexandre Carvalho,Carlos Capela,
Frontiers in microbiology (2023): 1266261
International journal of pharmaceutics (2022): 121954-121954
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