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The major scientific achievement of his group is the characterization of several mechanisms involved in immunosurveillance of acute and latent murine CMV (MCMV) infection. Working in close collaboration with Professor Ulrich Koszinowski (Germany) his group was the first to show that CD4 T cells are essential for control of horizontal virus spread and can compensate the function of CD8 T cells when these cells are depleted. They also showed that antibodies are not essential for primary CMV control and establishment of latency but are powerful mechanism in preventing the spread of recurrent virus. His group provided the first evidence that immunosurveillance of latent CMV infection is organized in a hierarchical and redundant fashion, with not only CD8 T cells but also CD4 T cells and NK cells playing an important role. The group pioneered the work on MCMV evasion of NK cells and characterized several viral proteins involved in downmodulation of NKG2D ligands. More recently, they established the MCMV model of congenital CMV infection of CNS and demonstrated impaired development of cerebellum of infected animals coupled with inflammatory lesions. They have also made a significant contribution to elucidating the recognition of MCMV infected cells by Ly49 NK cell receptors and molecular mechanism involved in specific recognition of infected cells by several activating Ly49 receptors. The group has been the first to show that ‘missing-self’ dependent NK cell activation plays a role in virus control and characterized viral immunoevasion of this effector mechanism.
Research Interests
Papers共 342 篇Author StatisticsCo-AuthorSimilar Experts
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CARBOHYDRATE POLYMERS (2024): 122349-122349
Scientific reportsno. 1 (2024): 13605-13605
JCI INSIGHTno. 11 (2024)
EUROPEAN JOURNAL OF IMMUNOLOGY (2023): 83-83
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Nature Communicationsno. 1 (2023): 1-17
European Heart Journalno. Supplement_2 (2023)
Jonathan D. Worboys,Katherine N. Vowell, Roseanna K. Hare,Ashley R. Ambrose,Margherita Bertuzzi,Michael A. Conner, Florence P. Patel, William H. Zammit,Judit Gali-Moya,Khodor S. Hazime, Katherine L. Jones,Camille Rey,
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Author Statistics
#Papers: 343
#Citation: 16597
H-Index: 65
G-Index: 123
Sociability: 7
Diversity: 3
Activity: 85
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