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Our research focuses on defining the molecular basis for HIV silencing, the signaling pathways used to reactivate latent HIV, the impact of drugs of abuse on the creation and reactivation of the latent viral reservoir in microglial cells, and the development of novel therapeutic approaches to attacking HIV latency. Key questions about HIV silencing that remain to be answered include:
What are the primary sequence triggers and mechanisms that induce silencing (i.e. protein repressors and/or viral-derived RNA)? What cellular pre-conditions lead to proviral silencing?
Do similar silencing mechanisms operate in each of the cell types infected by HIV?
How do drugs of abuse reactivate HIV?
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论文共 237 篇作者统计合作学者相似作者
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Current opinion in HIV and AIDSno. 3 (2024): 102-109
AIDS RESEARCH AND HUMAN RETROVIRUSESno. 1 (2024): 7-21
Methods in molecular biology (Clifton, N.J.) (2024): 209-227
Retrovirologyno. 1 (2024): 1-38
Debjit Khan,Fulvia Terenzi,GuanQun Liu,Prabar K. Ghosh,Fengchun Ye,Kien Nguyen,Arnab China,Iyappan Ramachandiran, Shruti Chakraborty, Jennifer Stefan,Krishnendu Khan,Kommireddy Vasu,
Nature Communicationsno. 1 (2023): 1-22
AIDS research and human retroviruses (2023)
JOURNAL OF NEUROVIROLOGY (2023): S35-S36
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