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My research program investigates the physiological regulation of arterial contractility and systemic blood pressure by ion channels expressed in smooth muscle and endothelial cells. My laboratory also examines pathological alterations in ion channels that are associated with cardiovascular diseases, including hypertension and stroke. Ion channels that we currently study include TRP, KV, ANO1 and CaV1.2 proteins. We use a broad range of techniques that incorporates the use of a molecular, biochemical, cellular, and functional approaches, making the research translational. Methods used in the laboratory include novel cell-specific gene knockout and cardiovascular disease models, RT-PCR, Western blotting, biotinylation, FRET, RNAi, co-IP, immunofluorescence, patch-clamp electrophysiology, membrane potential recording, intracellular Ca2+imaging, arterial myography and blood pressure telemetry.
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Papers共 252 篇Author StatisticsCo-AuthorSimilar Experts
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Proceedings of the National Academy of Sciencesno. 15 (2024): e2322135121-e2322135121
Somasundaram Raghavan,Masuma Akter Brishti, Angelica Bernardelli, Alejandro Mata-Daboin,Jonathan H Jaggar,M Dennis Leo
Ulrich C Mbiakop,Jonathan H Jaggar
Microcirculation (New York, N.Y. : 1994)no. 4 (2023): e12834-e12834
PHYSIOLOGYno. S1 (2023)
SCIENCE SIGNALINGno. 811 (2023): eadh9399-eadh9399
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICAno. 31 (2023): e2303238120-e2303238120
The Journal of physiology (2023)
bioRxiv : the preprint server for biology (2023)
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